anti-Phospholamban Phospho Serine-16 （A010-12）

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anti-Phospholamban Phospho Serine-16 (A010-12)

Description: A fully validated, highly specific polyclonal anti-serum to Serine-16 phosphorylated forms of phospholamban (PLB PS-16)

Background: Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca²⁺/CaM-dependent (Thr-17) protein kinases in response to β-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure

Unit Volume: 20 ul

Tested Applications: Western Blot (1:5000 dilution), ELISA

Antibody Form:  Lyophilised Rabbit anti-serum (IgG).

Species Recognition: All mammalian species, when phosphorylated on Ser-16.

Full Publication list: 114 papers

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