青霉素-链霉素（Penicillin-Streptomycin）是一种含有青霉素和链霉素的双抗溶液，二者浓度分别为Penicillin：10000 U/mL，Streptomycin：10000 µg/mL，作为培养基的一部分用于细胞培养，可有效抑制多数革兰氏阳性菌和革兰氏阴性菌的生长，从而有效控制细胞被细菌污染。

本品为无菌溶液，pH为6.3 – 6.9，作为100×储存液，推荐使用浓度为10 mL/L（Penicillin：100 U/mL；Streptomycin：100 μg/mL）。

组分信息

储存条件

-25~-15℃保存。有效期1年。

注意事项

1. 为了您的安全和健康，请穿实验服并戴一次性手套操作。

2. 本产品仅作科研用途。

产品应用场景和主要特点  

[1] Chen SW, Zhu SQ, Pei X, et al. Cancer cell-derived exosomal circUSP7 induces CD8⁺ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC. Mol Cancer. 2021;20(1):144. Published 2021 Nov 9. doi:10.1186/s12943-021-01448-x(IF:27.401)
[2] Zhang LX, Gao J, Long X, et al. The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis. Mol Cancer. 2022;21(1):110. Published 2022 May 7. doi:10.1186/s12943-022-01586-w(IF:27.401)
[3] Zhang W, Liu J, Li X, et al. Precise Chemodynamic Therapy of Cancer by Trifunctional Bacterium-Based Nanozymes. ACS Nano. 2021;15(12):19321-19333. doi:10.1021/acsnano.1c05605(IF:15.881)
[4] Xu YP, Dong ZN, Wang SW, et al. circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma. J Exp Clin Cancer Res. 2021;40(1):290. Published 2021 Sep 15. doi:10.1186/s13046-021-02095-2(IF:11.161)
[5] Yao C, Ni Z, Gong C, et al. Rocaglamide enhances NK cell-mediated killing of non-small cell lung cancer cells by inhibiting autophagy. Autophagy. 2018;14(10):1831-1844. doi:10.1080/15548627.2018.1489946(IF:11.100)
[6] Yu XN, Zhang GC, Liu HN, et al. Pre-mRNA processing factor 19 functions in DNA damage repair and radioresistance by modulating cyclin D1 in hepatocellular carcinoma. Mol Ther Nucleic Acids. 2021;27:390-403. Published 2021 Dec 9. doi:10.1016/j.omtn.2021.12.002(IF:8.886)
[7] Peng R, Cao J, Su BB, et al. Down-regulation of circPTTG1IP induces hepatocellular carcinoma development via miR-16-5p/RNF125/JAK1 axis. Cancer Lett. 2022;543:215778. doi:10.1016/j.canlet.2022.215778(IF:8.679)
[8] Jiang K, Zhao D, Ye R, et al. Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy. Nanoscale. 2022;14(5):1834-1846. Published 2022 Feb 3. doi:10.1039/d1nr06353g(IF:7.790)
[9] Wang M, Tang T, Li R, et al. Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. J Med Chem. 2022;65(5):4156-4181. doi:10.1021/acs.jmedchem.1c01993(IF:7.446)
[10] Ma H, Lin J, Li L, et al. Formaldehyde reinforces pro-inflammatory responses of macrophages through induction of glycolysis. Chemosphere. 2021;282:131149. doi:10.1016/j.chemosphere.2021.131149(IF:7.086)
[11] Ren S, Xu Y. AC016405.3, a novel long noncoding RNA, acts as a tumor suppressor through modulation of TET2 by microRNA-19a-5p sponging in glioblastoma. Cancer Sci. 2019;110(5):1621-1632. doi:10.1111/cas.14002(IF:6.716)
[12] Ren S, Xu Y. AC016405.3, a novel long noncoding RNA, acts as a tumor suppressor through modulation of TET2 by microRNA-19a-5p sponging in glioblastoma. Cancer Sci. 2019;110(5):1621-1632. doi:10.1111/cas.14002(IF:6.716)
[13] Yan X, Yao C, Fang C, et al. Rocaglamide promotes the infiltration and antitumor immunity of NK cells by activating cGAS-STING signaling in non-small cell lung cancer. Int J Biol Sci. 2022;18(2):585-598. Published 2022 Jan 1. doi:10.7150/ijbs.65019(IF:6.582)
[14] Liu W, Guan Y, Qiao S, et al. Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice. Oxid Med Cell Longev. 2021;2021:9942090. Published 2021 Aug 6. doi:10.1155/2021/9942090(IF:6.543)
[15] Guo J, Li Y, Gao Z, et al. 3D printed controllable microporous scaffolds support embryonic development in vitro [published online ahead of print, 2022 Jun 14]. J Cell Physiol. 2022;10.1002/jcp.30810. doi:10.1002/jcp.30810(IF:6.384)
[16] Rong R, Xia X, Peng H, et al. Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy. Cell Death Dis. 2020;11(9):720. Published 2020 Sep 3. doi:10.1038/s41419-020-02922-y(IF:6.304)
[17] Bu S, Wang Q, Sun J, Li X, Gu T, Lai D. Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis [published correction appears in Cell Death Dis. 2020 Sep 8;11(9):726]. Cell Death Dis. 2020;11(8):644. Published 2020 Aug 18. doi:10.1038/s41419-020-02906-y(IF:6.304)
[18] Chen Q, Yang Z, Ding H, Li H, Wang W, Pan Z. CircWHSC1 Promotes Breast Cancer Progression by Regulating the FASN/AMPK/mTOR Axis Through Sponging miR-195-5p. Front Oncol. 2022;11:649242. Published 2022 Jan 5. doi:10.3389/fonc.2021.649242(IF:6.244)
[19] Gao C, Wang SW, Lu JC, et al. KSR2-14-3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma. Biomark Res. 2022;10(1):25. Published 2022 Apr 25. doi:10.1186/s40364-022-00361-9(IF:6.148)
[20] Wang N, Yu M, Fu Y, Ma Z. Blocking ATM Attenuates SKOV3 Cell Proliferation and Migration by Disturbing OGT/OGA Expression via hsa-miR-542-5p. Front Oncol. 2022;12:839508. Published 2022 Jun 20. doi:10.3389/fonc.2022.839508(IF:5.738)
[21] Zhi W, Li S, Wan Y, Wu F, Hong L. Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy [published correction appears in Cancer Cell Int. 2022 Mar 21;22(1):131]. Cancer Cell Int. 2022;22(1):18. Published 2022 Jan 11. doi:10.1186/s12935-022-02447-8(IF:5.722)
[22] Luo Z, Jiang L, Ding C, et al. Surfactant Free Delivery of Docetaxel by Poly[(R)-3-hydroxybutyrate-(R)-3-hydroxyhexanoate]-Based Polymeric Micelles for Effective Melanoma Treatments. Adv Healthc Mater. 2018;7(23):e1801221. doi:10.1002/adhm.201801221(IF:5.609)
[23] Xia C, Qin X, Zhou L, et al. Reproductive Regulation of PrRPs in Teleost: The Link Between Feeding and Reproduction. Front Endocrinol (Lausanne). 2021;12:762826. Published 2021 Nov 3. doi:10.3389/fendo.2021.762826(IF:5.555)
[24] Hu D, Shen W, Gong C, et al. Grain-sized moxibustion promotes NK cell antitumour immunity by inhibiting adrenergic signalling in non-small cell lung cancer. J Cell Mol Med. 2021;25(6):2900-2908. doi:10.1111/jcmm.16320(IF:5.310)
[25] Yu Q, Dai W, Ji J, et al. Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c-myc/hexokinase 2 pathway. J Cell Mol Med. 2022;26(10):3031-3045. doi:10.1111/jcmm.17322(IF:5.310)
[26] Luo Z , Xue K , Zhang X , et al. Thermogelling chitosan-based polymers for the treatment of oral mucosa ulcers. Biomater Sci. 2020;8(5):1364-1379. doi:10.1039/c9bm01754b(IF:5.251)
[27] Wang Y, Chen K, Cai Y, et al. Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma. J Exp Clin Cancer Res. 2017;36(1):111. Published 2017 Aug 16. doi:10.1186/s13046-017-0581-6(IF:5.189)
[28] Liu XF, Zhu XD, Feng LH, et al. Physical activity improves outcomes of combined lenvatinib plus anti-PD-1 therapy in unresectable hepatocellular carcinoma: a retrospective study and mouse model. Exp Hematol Oncol. 2022;11(1):20. Published 2022 Apr 4. doi:10.1186/s40164-022-00275-0(IF:5.133)
[29] Yao F, Zhang X, Yao X, et al. Peroxisome Proliferator-Activated Receptor α Activation Protects Retinal Ganglion Cells in Ischemia-Reperfusion Retinas. Front Med (Lausanne). 2021;8:788663. Published 2021 Dec 23. doi:10.3389/fmed.2021.788663(IF:5.093)
[30] Liu Y, Xu C, Fan X, Loh XJ, Wu YL, Li Z. Preparation of mixed micelles carrying folates and stable radicals through PLA stereocomplexation for drug delivery. Mater Sci Eng C Mater Biol Appl. 2020;108:110464. doi:10.1016/j.msec.2019.110464(IF:4.959)
[31] Liu W, Lin H, Mao Z, et al. Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy. Aging (Albany NY). 2020;12(6):5300-5317. doi:10.18632/aging.102951(IF:4.831)
[32] Zhu M, Wei C, Lin J, et al. UHRF1 is regulated by miR-124-3p and promotes cell proliferation in intrahepatic cholangiocarcinoma. J Cell Physiol. 2019;234(11):19875-19885. doi:10.1002/jcp.28586(IF:4.522)
[33] Li D, Ma H, Shu Q, et al. Arsenite inhibits M2a polarization of macrophages through downregulation of peroxisome proliferator-activated receptor gamma [published online ahead of print, 2022 Jun 28]. Toxicol Appl Pharmacol. 2022;450:116142. doi:10.1016/j.taap.2022.116142(IF:4.460)
[34] He P, Cheng S, Hu F, Ma Z, Xia Y. Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer. BMC Cancer. 2021;21(1):252. Published 2021 Mar 9. doi:10.1186/s12885-021-07976-5(IF:4.430)
[35] Xie X, Hu L, Liu L, et al. Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway. Transl Oncol. 2022;19:101388. doi:10.1016/j.tranon.2022.101388(IF:4.243)
[36] Ma H, Ding Z, Xie Y, et al. Methylglyoxal produced by tumor cells through formaldehyde-enhanced Warburg effect potentiated polarization of tumor-associated macrophages. Toxicol Appl Pharmacol. 2022;438:115910. doi:10.1016/j.taap.2022.115910(IF:4.219)
[37] Wu Q, Hu Y, Jiang M, Wang F, Gong G. Effect of Autophagy Regulated by Sirt1/FoxO1 Pathway on the Release of Factors Promoting Thrombosis from Vascular Endothelial Cells. Int J Mol Sci. 2019;20(17):4132. Published 2019 Aug 24. doi:10.3390/ijms20174132(IF:4.183)
[38] Duan Y, Huang W, Zhan B, et al. A Bioink Derived From Human Placenta Supporting Angiogenesis [published online ahead of print, 2022 Jun 22]. Biomed Mater. 2022;10.1088/1748-605X/ac7b5b. doi:10.1088/1748-605X/ac7b5b(IF:4.103)
[39] Zhang Y, Li Y, Wang Q, et al. Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways. Int J Mol Med. 2022;49(2):13. doi:10.3892/ijmm.2021.5068(IF:4.101)
[40] Wang N, Lu L, Cao QF, et al. Partial inhibition of activin receptor-like kinase 4 alleviates bladder fibrosis caused by bladder outlet obstruction. Exp Cell Res. 2021;406(1):112724. doi:10.1016/j.yexcr.2021.112724(IF:3.905)
[41] Li B, Bu S, Sun J, Guo Y, Lai D. Artemisinin derivatives inhibit epithelial ovarian cancer cells via autophagy-mediated cell cycle arrest. Acta Biochim Biophys Sin (Shanghai). 2018;50(12):1227-1235. doi:10.1093/abbs/gmy125(IF:3.848)
[42] Zheng Y, Ke L, Lu Y, et al. Enhanced Healing and Antimicrobial Efficacy of Chitosan-g-Polyacrylamide in a Rat Model of Gingival Ulcers. Front Chem. 2020;8:273. Published 2020 Apr 24. doi:10.3389/fchem.2020.00273(IF:3.693)
[43] Zhao Z, Song J, Zhang D, Wu F, Tu J, Ji J. Oxysophocarpine suppresses FGFR1-overexpressed hepatocellular carcinoma growth and sensitizes the therapeutic effect of lenvatinib. Life Sci. 2021;264:118642. doi:10.1016/j.lfs.2020.118642(IF:3.647)
[44] Liu M, Tao J, Guo H, et al. Efficacy of Water-Soluble Pearl Powder Components Extracted by a CO₂ Supercritical Extraction System in Promoting Wound Healing. Materials (Basel). 2021;14(16):4458. Published 2021 Aug 9. doi:10.3390/ma14164458(IF:3.623)
[45] Xie H, Zhang C, Zhang J, et al. An in vitro cell model to study microglia activation in diabetic retinopathy. Cell Biol Int. 2022;46(1):129-138. doi:10.1002/cbin.11710(IF:3.612)
[46] Ng W, Gong C, Yan X, et al. Targeting CD155 by rediocide-A overcomes tumour immuno-resistance to natural killer cells. Pharm Biol. 2021;59(1):47-53. doi:10.1080/13880209.2020.1865410(IF:3.503)
[47] Wang Z, Wu J, Jiang J, et al. KIF2A decreases IL-33 production and attenuates allergic asthmatic inflammation. Allergy Asthma Clin Immunol. 2022;18(1):55. Published 2022 Jun 19. doi:10.1186/s13223-022-00697-9(IF:3.406)
[48] Wang X, Lou K, Song X, et al. Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020;396:115001. doi:10.1016/j.taap.2020.115001(IF:3.347)
[49] Chu P, He L, Yang C, et al. Grass carp ATG5 and ATG12 promote autophagy but down-regulate the transcriptional expression levels of IFN-I signaling pathway. Fish Shellfish Immunol. 2019;92:600-611. doi:10.1016/j.fsi.2019.06.014(IF:3.298)
[50] Wang K, Gu Y, Ni J, et al. Noncoding-RNA mediated high expression of zinc finger protein 268 suppresses clear cell renal cell carcinoma progression by promoting apoptosis and regulating immune cell infiltration. Bioengineered. 2022;13(4):10467-10481. doi:10.1080/21655979.2022.2060787(IF:3.269)
[51] Wang X, Xie D, Dai H, Ye J, Liu Y, Fei A. Clemastine protects against sepsis-induced myocardial injury in vivo and in vitro. Bioengineered. 2022;13(3):7134-7146. doi:10.1080/21655979.2022.2047256(IF:3.269)
[52] Huang D, Xiong M, Xu X, et al. Bile acids elevated by high-fat feeding induce endoplasmic reticulum stress in intestinal stem cells and contribute to mucosal barrier damage. Biochem Biophys Res Commun. 2020;529(2):289-295. doi:10.1016/j.bbrc.2020.05.226(IF:2.985)
[53] Ma H, Song X, Huang P, et al. Myricetin protects natural killer cells from arsenite induced DNA damage by attenuating oxidative stress and retaining poly(ADP-Ribose) polymerase 1 activity. Mutat Res Genet Toxicol Environ Mutagen. 2021;865:503337. doi:10.1016/j.mrgentox.2021.503337(IF:2.873)
[54] Wang D, Xue Z, Wu H, Shi G, Feng S, Zhao L. Hepatoprotective effect and structural analysis of Hedysarum polysaccharides in vivo and in vitro [published online ahead of print, 2022 Apr 28]. J Food Biochem. 2022;e14188. doi:10.1111/jfbc.14188(IF:2.720)
[55] Xiao L, Zhang S, Zheng Q, Zhang S. Dysregulation of KIF14 regulates the cell cycle and predicts poor prognosis in cervical cancer: a study based on integrated approaches. Braz J Med Biol Res. 2021;54(11):e11363. Published 2021 Sep 3. doi:10.1590/1414-431X2021e11363(IF:2.590)
[56] Niu X, Lin X, Chen X, Xu S, Huang Z, Tang Q. Long-wave Ultraviolet Ray Promotes Inflammation in Keloid-derived Fibroblasts by Activating P38-NFκB1 Signaling Pathway. J Burn Care Res. 2020;41(6):1231-1239. doi:10.1093/jbcr/iraa075(IF:1.533)
[57] Liu L, Sun L, Zheng J, Cui L. Berberine modulates Keratin 17 to inhibit cervical cancer cell viability and metastasis. J Recept Signal Transduct Res. 2021;41(6):521-531. doi:10.1080/10799893.2020.1830110(IF:1.466)