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Kamiya Biomedical Company是一家1983年3月成立的美国生命科学技术公司，总部位于美国加利福尼亚州。本公司致力于为生命科学研究和医药机构提供高质量的具有创新性的基础研究和诊断试剂。
公司的zui早的生命科学研究产品是用于信号转导研究用蛋白酶抑制剂staurosporine和K252a。1990年，KAMIYA*家在美国推出凋亡研究的重要抗体anti-Fas单克隆抗体。1997年推出了一个完整的临床诊断和研究用免疫检测产品线，生产基于免疫投射比浊法(immunoturbidimetric technology)的脂质测定、凝血、炎症、糖尿病、营养评估及血脂蛋白测定试剂及试剂盒。公司研发的K-ASSAY试剂无需搅拌、溶解和稀释样本等繁杂程序。
如今，KAMIYA供应的生命科学系列产品包括世界上zui大的ELISA试剂盒产品线，上万种人类的生物标志物分析的产品、酶抑制剂、单抗、多抗。产品广泛应用于细胞凋亡、多抗药性、氧化/ DNA损坏和修复、骨生物学、癌症、心脏健康、炎症、压力与应激、肥胖和糖尿病等研究领域。
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| 抗体 |
| 产品 |
克隆 |
主办 |
反应 |
应用 |
数量 |
货号 |
| LSD1（IN），（赖氨酸特异性组蛋白脱甲基酶） |
多克隆 |
兔子 |
人，老鼠，老鼠 |
蛋白质印迹 |
100μg |
PC-543 |
品名: Anti-LSD1 pAb
货号: PC-543 (100 µg)
Synonyms:Anti-Lysine-Specific Histone Demethylase, anti-Amine Oxidase Flavin Containing Domain Protein 2, anti-AOF2.
Format:100 µg of polyclonal antibody in PBS containing
0.02% sodium azide. Purified by immunoaffinity chromatography.
Background:
Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing co-repressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.
Storage: Store at 4°C.
Applications and Suggested Dilutions: Western blot: Use at 1 – 2 µg/mL.
Immunohistochemistry: Use at ~ 2 µg/mL.
The optimal dilution for a specific application should be determined by the researcher.
Figure 1: Western blot analysis of LSD1 in P815 cell lysate with anti-LSD1 pAb at (A) 1 µg/mL and (B) 2 µg/mL.
Specificity: Recognizes LSD1.
Positive Control: P815 cell lysate.
Species Reactivity:
Human, mouse and rat. Other species not tested.
Host: Rabbit
Immunogen:
Raised against a 16 amino acid peptide from near the center of human LSD1 (Genbank accession No. NP_001009999).
Figure 2: Immunohistochemistry of LSD1 in human small intestine tissue with LSD1 antibody at 2 µg/mL.
Limitations:For in vitro research use only. Not for use in diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made regarding the use of this product. KAMIYA BIOMEDICAL COMPANY is not liable for any damage,
personal injury, or economic loss caused by this product.
