levenabiopharma用于连接抗体和药物的连接子
levenabiopharma生物制药提供不同结构和功能的多种连接子，可用于抗体和药物的偶联的连接子。更重要的是，联宁自主开发的拥有*知识产权的连接子可以将药物可控地偶联到抗体上，更易实现批次间的产品质量控制。为更好地支持客户的药物开发，levenabiopharma还提供连接子定制设计和合成服务。
levenabiopharma产品目录
| 产品目录号 | 产品名称 | Cas 号 | 纯度 | 可提供数量 |
| VC1001 | Val-Cit-PAB | 159857-79-1 | 95% | mg – 500g |
| VC1002 | Fmoc-Val-Cit-PAB | 159858-22-7 | 95% | mg – 500g |
| VC1003 | Fmoc-Val-Cit-PAB-PNP | 863971-53-3 | 95% | mg – 500g |
| VC1004 | MC-Val-Cit-PAB-PNP | 159857-81-5 | 95% | mg-100g |
| FK1001 | Phe-Lys(Trt)-PAB | 95% | mg – kg | |
| FK1002 | Fmoc-Phe-Lys(Trt)-PAB | 95% | mg – kg | |
| FK1003 | Fmoc-Phe -Lys(Trt)-PAB-PNP |
1116086-09-9 | 95% | mg – kg |
| AN1001 | Ala-Ala-Asn-PAB TFA salt | 95% | mg – kg | |
| AN1002 | Fmoc-Ala-Ala-Asn-PAB-PNP | 95% | mg – kg | |
| H1001 | Fmoc-Gly3-Val-Cit-PAB | 95% | mg-100g | |
| H1002 | Fmoc-Gly3-Val-Cit-PAB-PNP | 95% | mg-100g | |
| D1000 | SMCC | 64987-85-5 | 98% | 500mg-500g |
| DS1001 | Py-ds-Prp-OSu | 95% | mg – kg | |
| DS1003 | Py-ds-dmBut-OSu | 95% | mg – 100g | |
| DS1013 | Py-ds-dmBut-OPFP | 95% | mg – 100g | |
| DS1011 | Py-ds-Prp-OPFP | 95% | mg – kg | |
| MA1000 | MAL-HA-OSu | 95% | mg – kg | |
| MA2011 | MAL-di-EG-OPFP | 95% | mg – kg | |
| MA2012 | MAL-tri-EG-OPFP | 95% | mg – kg | |
| MA2013 | MAL-tetra-EG-OPFP | 95% | mg – kg | |
| AZ1011 | N3-di-EG-OPFP | 95% | mg – kg | |
| AZ1012 | N3-tri-EG-OPFP | 95% | mg – kg | |
| AZ1013 | N3-tetra-EG-OPFP | 95% | mg – kg | |
| AL1001 | ALD-BZ-OSu | 95% | mg – kg | |
| AL1003 | ALD-di-EG-OSu | 95% | mg – kg | |
| AL1005 | ALD-tetra-EG-OSu | 95% | mg – kg | |
| AL1013 | ALD-di-EG-OPFP | 95% | mg – kg | |
| AL1015 | ALD-tetra-EG-OPFP | 95% | mg – kg | |
| HA1011 | PHA-di-EG-OPFP | 95% | mg – kg | |
| HA1013 | PHA-tetra-EG-OPFP | 95% | mg – kg |
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ADC细胞毒素药物
抗体药物偶联物细胞毒素药物
从抗体到靶向抗体药物偶联物的合成过程有挑战性。为了设计出高效的抗体药物偶联物，毒素的选择是至关重要的。联宁生物制药提供各种各样的微管蛋白抑制剂和DNA烷基化试剂，这些试剂已被证实是抗体药物偶联物负载的有效细胞毒素。对下面列出的这些毒素， 联宁可以提供毫克级至100克级的高质量产品。
For structures, click here>>>
| 产品目录号 | 产品名称 | Cas 号 | 纯度 | 可提供数量 |
| T1001 | Dolastatin 10 | 110417-88-4 | 98% | mg – 100g |
| T1002 | Monomethyl Dolastatin 10 | 203849-91-6 | 98% | mg – 100g |
| T1003 | Auristatin E | 160800-57-7 | 98% | mg – 100g |
| T1004 | Monomethyl Auristatin E | 474645-27-7 | 98% | mg – 100g |
| T1005 | Auristatin F | 163768-50-1 | 98% | mg – 100g |
| T1006 | Monomethyl Auristatin F | 745017-94-1 | 98% | mg – 100g |
| T1007 | HTI-286 | 228266-40-8 | 95% | mg – g |
| T1008 | Tubulysin M | 205304-86-5 | 95% | mg – g |
| T1009 | Maytansinoid AP-3 | 66547-09-9 | 85% | mg |
| T1109 | Maytansinol | 57103-68-1 | 95% | mg – 100g |
| LN-T-4582 | DM1 | 139504-50-0 | 98% | mg – 100g |
| LN-T-7544 | DM4 | 799840-96-3 | 98% | mg – 10g |
| T1102 | Boc-Val-Dil-Dap-OH | 95% | mg – kg | |
| T1202 | Boc-Val-Dil-Dap-Phe-OMe | 95% | mg – kg | |
| T1222 | Boc-Val-Dil-Dap-Doe | 95% | mg – kg | |
| T1224 | Boc-Val-Dil-Dap-Nrp | 95% | mg – kg | |
| T1302 | Boc-N-Me-Val-Val-Dil-Dap-OH | 95% | mg – kg | |
| T1108 | Tubulysin IM-1 | 95% | mg – 100g | |
| T1208 | Tubulysin IM-2 | 95% | mg – 100g | |
| T1308 | Tubulysin IM-3 | 95% | mg – 100g | |
| D1001 | Duocarmycin SA | 152785-82-5 | 95% | mg – g |
| D1007 | Duocarmycin TM | 95% | mg – g | |
| D1008 | Duocarmycin MA | 95% | mg – g | |
| D1009 | Duocarmycin DM | 95% | mg – g | |
| D4000 | Nemorubicin | 108852-90-0 | 95% | mg – 10 g |
| D4001 | PNU-159682 | 202350-68-3 | >90% | mg -10 g |
| LN-T-6888 | Calicheamicin g1 | 108212-75-5 | >95% | mg-100mg |
| D4006 | N-Acetyl-Calicheamicin g1 | 108212-76-6 | >95% | mg-100g |
| D4007 | a-Amanitin | 23109-05-9 | >95% | mg-g |
| D4008 | PBD-dimer | 1222490-34-7 | >90% | mg-100mg |
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易用的细胞毒素 (SET™)
安全易用的毒素（SET™)
联宁生物制药提供安全易用的毒素（SET™），这是一种可以快速筛选抗体药物偶联物的新型研究工具。SET™产品线包括很多已验证的连接子-毒素，分别装入预包装好的小瓶中。每个SET™小瓶含有约200纳摩的连接子-毒素，按药物/抗体比（DAR）为3-4计算的话， 足够偶联5毫克抗体。客户不需要称重或分装连接子-毒素，只需按照产品说明书上提供的溶解方案，即可使用SET™。SET™不仅易于使用，更重要的是可以大限度地减少实验过程中暴露毒素的风险。目前，SET™可用于以下类别的偶联反应：
❖胺反应SET™
❖硫醇反应SET™
❖点击反应SET™
❖转肽酶反应 SET™
For structures, click here>>>
| 胺反应 SET™ | |||
| 产品目录号 | 产品名称 | 数量 | 单价 |
| SET0100 | OSu-Glu-vc-PAB-MMAE | 200 nmol | $500 |
| SET0101 | SMCC-DM1 | 200 nmol | $500 |
| SET0102 | SPDB-DM4 | 200 nmol | $650 |
| SET0103 | OSu-PEG4-vc-PAB-DMEA Duocarmycin SA |
200 nmol | $750 |
| SET0104 | Mylotarg-linker | 200 nmol | $950 |
| SET0105 | OSu-Glu-vc-PAB-MMAD | 200 nmol | $500 |
| SET0106 | Sulfo-SPDB-DM4 | 200 nmol | $950.00 |
| SET0107 | IMGN779-linker | 200 nmol | $2,200.00 |
| SET0108 | OSu-PEG4-vc-PAB-DMEA Duocarmycin TM |
200 nmol | $750.00 |
| SET0109 | OSu-PEG4-vc-PAB-DMEA Duocarmycin DM |
200 nmol | $750.00 |
| 硫醇反应SET™ | |||
| 产品目录号 | 产品名称 | 数量 | 单价 |
| SET0201 | MC-vc-PAB-MMAE | 200 nmol | $ 500 |
| SET0202 | MC-MMAF | 200 nmol | $ 500 |
| SET0203 | MC-DM1 | 200 nmol | $ 700 |
| SET0204 | MC-MMD-10 | 200 nmol | $ 600 |
| SET0205 | MA-PEG4-vc-PAB-DMEA- duocarmycin SA |
200 nmol | $ 750 |
| SET0206 | MC-vc-PAB-C6-a-amanitin | 200 nmol | $ 850 |
| SET0207 | MC-cleavable-linker-a-amanitin | 200 nmol | $ 600 |
| SET0208 | MC-vc-PAB-DMEA-(PEG2)- duocarmycin SA |
200 nmol | $ 800 |
| SET0209 | MC-vc-PAB-Tubulysin M | 200 nmol | $ 800 |
| SET0210 | MC-va-PAB-MMAD | 200 nmol | $ 500 |
| SET0211 | MA-PEG4-VC-PAB-DMAE-PNU159682 | 200 nmol | $ 950 |
| SET0212 | MA-PEG4-VA-PBD | 200 nmol | $ 1,100 |
| SET0213 | MC-vc-PAB-MMAF | 200 nmol | $ 500 |
| SET0214 | MC-vc-PAB-MMAD | 200 nmol | $ 500 |
| SET0215 | MC-vc-PAB-Auristatin 0101 | 200 nmol | $ 900 |
| SET0216 | MA-PEG8-VA-PAB-SG3199 | 200 nmol | $ 1,950 |
| SET0217 | CL2A-SN 38 | 200 nmol | $ 800 |
| SET0218 | MC-GGFG-DX8951 | 200 nmol | $ 950 |
| SET0219 | MEDI4276_linker payload | 200 nmol | $ 1,100 |
| SET0220 | MA-PEG4-vc-PAB-DMEA- duocarmycin TM |
200 nmol | $ 750 |
| SET0221 | MC-vc-PAB-(PEG2)- duocarmycin TM |
200 nmol | $ 900 |
| SET0222 | MA-PEG4-vc-PAB-DMEA- duocarmycin DM |
200 nmol | $ 750 |
| SET0223 | MC-vc-PAB-(PEG2)- duocarmycin DM |
200 nmol | $ 900 |
| SET0224 | DGN549 | 200 nmol | $ 1,900 |
| SET0225 | MPB-vc-PAB-MMAE | 200 nmol | $ 550 |
| SET0226 | MPB-MMAF | 200 nmol | $ 550 |
| 点击反应SET™ | |||
| 产品目录号 | 产品名称 | 数量 | 单价 |
| SET0301 | DBCO-PEG4-vc-PAB-MMAE | 200 nmol | $ 650 |
| SET0302 | DBCO-PEG4-MMAF | 200 nmol | $ 750 |
| SET0303 | DBCO-PEG4-Ahx-DM1 | 200 nmol | $ 750 |
| SET0304 | DBCO-PEG4-vc-PAB- Duocarmycin SA |
200 nmol | $ 900 |
| SET0305 | DBCO-PEG4-vc-PAB-(PEG2)- Duocarmycin SA |
200 nmol | $ 1,050 |
| SET0306 | DBCO-PEG4-VA-PBD | 200 nmol | $ 1,100 |
| SET0307 | DBCO-PEG4-vc-PAB-MMAF | 200 nmol | $ 650 |
| SET0308 | DBCO-PEG4-vc-PAB-MMAD | 200 nmol | $ 650 |
| SET0309 | DBCO-PEG4-vc-PAB- Duocarmycin TM |
200 nmol | $ 900 |
| SET0310 | DBCO-PEG4-vc-PAB-(PEG2)- Duocarmycin TM |
200 nmol | $ 1,050 |
| SET0311 | DBCO-PEG4-vc-PAB- Duocarmycin DM |
200 nmol | $ 900 |
| SET0312 | DBCO-PEG4-vc-PAB-(PEG2)- Duocarmycin DM |
200 nmol | $ 1,050 |
| SET0313 | DBCO-PEG4-VC-PAB-DMAE-PNU159682 | 200 nmol | $ 1,050 |
| SET0314 | DBCO-PEG4-DMAE-PNU159682 | 200 nmol | $ 1,000 |
| SET0315 | DBCO-PEG4-GGFG-DX8951 | 200 nmol | $ 1,050 |
| SET0316 | DBCO-PEG4-vc-PAB-Ahx-DM1 | 200 nmol | $ 850 |
| SET0317 | DBCO-PEG8-VA-PAB-SG3199 | 200 nmol | $ 2,050 |
| 转肽酶反应 SET™ | |||
| 产品目录号 | 产品名称 | 数量 | 单价 |
| SET0401 | Gly3-vc-PAB-MMAE | 200 nmol | $850 |
| SET0402 | Gly3-MMAF | 200 nmol | $850 |
| SET0403 | Gly5-Ahx-DM1 | 200 nmol | $950 |
| SET0404 | PNU159682-EDA-Gly3 | 200 nmol | $1,100 |
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ADC筛选试剂盒
抗体药物偶联物筛选试剂盒
联宁生物制药提供研究阶段抗体药物偶联物体外活性的筛选服务。公司的细胞库拥有超过100个癌细胞株，可以帮助客户评估抗体药物偶联物的细胞毒性和治疗潜力。公司还可以根据客户的需求灵活安排用这些细胞株来筛选抗体药物偶联物。
联宁生物制药制备了目前市面上常用的抗体药物偶联物，如T-DM1，brentuximab vedotin，VEGR2-ADC等，作为抗体药物偶联物评估的对照物，为客户评估抗体药物偶联物生物仿制药提供方便。
联宁生物制药开发的以蛋白A和蛋白G的PSKA™和PSKG™的抗体药物偶联物预筛选试剂盒，在不做偶联的情况下， 可以快速鉴定适合抗体药物偶联物研发用的抗体。使用这些试剂盒，可以直接筛选初级抗体，略去单独将毒素偶联到抗体上的过程。我们提供的PSK筛选试剂盒包括业界常用毒素，如MMAE，MMAF，DM1和duocarmycin。
| 产品目录号 | 产品名称 | 产品说明 | 数量 | 单价 |
| LEV-PSKA-100 | ADC pre-screening kit A | Four vials containing Protein A preloaded with 1x MMAE (cleavable linker) 1x MMAF (non-cleavable linker) 1x MCC-DM1 (non-cleavable linker) 1x Duocarmycin (cleavable linker) |
4×100 µL | $ 900.00 |
| LEV-ADM-100 | Protein A-DM1 | Protein A preloaded with MCC-DM1 (non-cleavable linker) | 100 µL | $ 300.00 |
| LEV-AME-100 | Protein A-MMAE | Protein A preloaded with MMAE (cleavable linker) | 100 µL | $ 300.00 |
| LEV-AMF-100 | Protein A-MMAF | Protein A preloaded with MMAF (non-cleavable linker) | 100 µL | $ 300.00 |
| LEV-ADC-100 | Protein A-Duocarmycin | Protein A preloaded with Duocarmycin (cleavable linker) | 100 µL | $ 400.00 |
| LEV-ACC-100 | Protein A-Calicheamicin | Protein A preloaded with Calicheamicin (cleavable linker) | 100 µL | $ 400.00 |
| LEV-APB-100 | Protein A-PBD | Protein A preloaded with PBD | 100 µL | $ 400.00 |
| LEV-PSKG-100 | ADC pre-screening kit G | Four vials containing Protein A preloaded with 1x MMAE (cleavable linker) 1x MMAF (non-cleavable linker) 1x MCC-DM1 (non-cleavable linker) 1x Duocarmycin (cleavable linker) |
4×100 µL | $ 900.00 |
| LEV-GDM-100 | Protein G-DM1 | Protein G preloaded with MCC-DM1 (non-cleavable linker) | 100 µL | $ 300.00 |
| LEV-GME-100 | Protein G-MMAE | Protein G preloaded with MMAE (cleavable linker) | 100 µL | $ 300.00 |
| LEV-GMF-100 | Protein G-MMAF | Protein G preloaded with MMAF (non-cleavable linker) | 100 µL | $ 300.00 |
| LEV-GDC-100 | Protein G-Duocarmycin | Protein G preloaded with Duocarmycin (cleavable linker) | 100 µL | $ 400.00 |
| LEV-GAM-100 | Protein G-Amanitin | Protein G preloaded with Amanitin (cleavable linker) | 100 µL | $ 400.00 |
| LEV-GAL-100 | Protein G-Amanitin | Protein G preloaded with Amanitin (Levena cleaveable linker) | 100 µL | $ 400.00 |
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抗细胞毒性药物抗体
抗细胞毒性药物抗体
联宁生物制药开发了各种抗细胞毒性药物抗体用来支持客户的临床前药物研究。目前，提供的抗体包括针对不同类别的细胞毒性药物的抗毒素（药物）单克隆和多克隆抗体。这些产品仅限于科研，不能用于临床诊断
| 产品目录号 | 产品名称 | 毒素类型 | 微升 | 单价 | 毫克/毫升 |
| LEV-PAE1-100 | Rabbit Anti-vc-PAB-MMAE pAb | Tubulin Inhibitor | 100 | $ 500.00 | 1 |
| LEV-PAE1-500 | 500 | $ 1,875.00 | |||
| LEV-MAE1-100 | Mouse Anti-vc-PAB-MMAE mAb (B11F11) | Tubulin Inhibitor | 100 | $ 900.00 | 1 |
| LEV-MAE1-500 | 500 | $ 3,375.00 | |||
| LEV-PAF1-100 | Rabbit Anti-MMAF pAb | Tubulin Inhibitor | 100 | $ 500.00 | 1 |
| LEV-PAF1-500 | 500 | $ 1,875.00 | |||
| LEV-MAF1-100 | Mouse Anti-MMAF mAb (F3B11) | Tubulin Inhibitor | 100 | $ 900.00 | 1 |
| LEV-MAF1-500 | 500 | $ 3,375.00 | |||
| LEV-MAE3-100 | Mouse Anti-MMAE / F mAb (B12A2) | Tubulin Inhibitor | 100 | $ 900.00 | 1 |
| LEV-MAE3-500 | 500 | $ 3,375.00 | |||
| LEV-MAF3-100 | Mouse Anti-MMAE /F mAb (C12A1) | Tubulin Inhibitor | 100 | $ 900.00 | 1 |
| LEV-MAF3-500 | 500 | $ 3,375.00 | |||
| LEV-PDM1-100 | Rabbit Anti-DM1/4 pAb | Tubulin Inhibitor | 100 | $ 500.00 | 1 |
| LEV-PDM1-500 | 500 | $ 1,875.00 | |||
| LEV-MDM1-100 | Mouse Anti-DM1/4 mAb (F1D5) | Tubulin Inhibitor | 100 | $ 900.00 | 1 |
| LEV-MDM1-500 | 500 | $ 3,375.00 | |||
| LEV-MDM2-100 | Mouse Anti-DM1/4 mAb (G2F3) | Tubulin Inhibitor | 100 | $ 900.00 | 1 |
| LEV-MDM2-500 | 500 | $ 3,375.00 | |||
| LEV-PCA1-100 | Rabbit Anti-Calicheamicin pAb | DNA Damaging | 100 | $ 750.00 | 0.5 |
| LEV-PCA1-500 | 500 | $ 2,800.00 | |||
| LEV-MCA1-100 | Mouse Anti-Calicheamicin mAb (B1G9) | DNA Damaging | 100 | $ 1,250.00 | 0.5 |
| LEV-MCA1-500 | 500 | $ 4,700.00 | |||
| LEV-MCA2-100 | Mouse Anti-Calicheamicin mAb (C1F12) | DNA Damaging | 100 | $ 1,250.00 | 0.5 |
| LEV-MCA2-500 | 500 | $ 4,700.00 | |||
| LEV-PDU1-100 | Rabbit Anti-Duocarmycin pAb | DNA Damaging | 100 | $ 750.00 | 0.5 |
| LEV-PDU1-500 | 500 | $ 2,800.00 | |||
| LEV-MDU3-100 | Mouse Anti-Duocarmycin mAb (E11A1) | DNA Damaging | 100 | $ 900.00 | 0.5 |
| LEV-MDU3-500 | 500 | $ 3,375.00 | |||
| LEV-MDU1-100 | Mouse Anti-Duocarmycin mAb (H7A9) | DNA Damaging | 100 | $ 900.00 | 0.5 |
| LEV-MDU1-500 | 500 | $ 3,375.00 | |||
| LEV-MDU2-100 | Mouse Anti-Duocarmycin mAb (E6B3) | DNA Damaging | 100 | $ 900.00 | 0.5 |
| LEV-MDU2-500 | 500 | $ 3,375.00 | |||
| LEV-PPN1-100 | Rabbit Anti-PNU-159682 pAb | DNA Damaging | 100 | $ 750.00 | 0.5 |
| LEV-PPN1-500 | 500 | $ 2,800.00 | |||
| LEV-MPN1-100 | Mouse Anti-PNU-159682 mAb (F7F2) | DNA Damaging | 100 | $ 900.00 | 0.5 |
| LEV-MPN1-500 | 500 | $ 3,375.00 | |||
| LEV-MPN2-100 | Mouse Anti-PNU-159682 mAb (C1E3) | DNA Damaging | 100 | $ 900.00 | 0.5 |
| LEV-MPN2-500 | 500 | $ 3,375.00 | |||
| LEV-MPN3-100 | Mouse Anti-PNU-159682 mAb (D12H11) | DNA Damaging | 100 | $ 900.00 | 0.5 |
| LEV-MPN3-500 | 500 | $ 3,375.00 | |||
| LEV-PAM1-100 | Rabbit Anti-Amanitin pAb | RNA Polymerase II and III Inhibitor | 100 | $ 650.00 | 0.5 |
| LEV-PAM1-500 | 500 | $ 2,450.00 | |||
| LEV-MAM1-100 | Mouse Anti-Amanitin mAb (H3E1) | RNA Polymerase II and III Inhibitor | 100 | $ 1,100.00 | 0.5 |
| LEV-MAM1-500 | 500 | $ 4,100.00 | |||
| LEV-MAM2-100 | Mouse Anti-Amanitin mAb (H12D6) | RNA Polymerase II and III Inhibitor | 100 | $ 1,100.00 | 0.5 |
| LEV-MAM2-500 | 500 | $ 4,100.00 | |||
| LEV-MAM3-100 | Mouse Anti-Amanitin mAb (C2C4) | RNA Polymerase II and III Inhibitor | 100 | $ 1,100.00 | 0.5 |
| LEV-MAM3-500 | 500 | $ 4,100.00 | |||
| LEV-PSN1-100 | Rabbit Anti-SN38 pAb | DNA Topoisomerase I Inhibitor | 100 | $ 650.00 | 0.5 |
| LEV-PSN1-500 | 500 | $ 2,450.00 | |||
| LEV-MSN1-100 | Mouse Anti-SN38 mAb (10F11A9D6) | DNA Topoisomerase I Inhibitor | 100 | $ 900.00 | 0.5 |
| LEV-MSN1-500 | 500 | $ 3,375.00 | |||
| LEV-MSN2-100 | Mouse Anti-SN38 mAb (8E10F12F3) | DNA Topoisomerase I Inhibitor | 100 | $ 900.00 | 0.5 |
| LEV-MSN2-500 | 500 | $ 3,375.00 | |||
| LEV-MSN3-100 | Mouse Anti-SN38 mAb (8E10A4A1) | DNA Topoisomerase I Inhibitor | 100 | $ 900.00 | 0.5 |
| LEV-MSN3-500 | 500 | $ 3,375.00 | |||
| LEV-PSG1-100 | Rabbit Anti-PBD SG3199 pAb | DNA Inhibitor | 100 | $ 900.00 | 0.5 |
| LEV-PSG1-500 | 500 | $ 3,374.00 | |||
| LEV-MSG1-100 | Mouse Anti-PBD SG3199 (7H6H9A6) mAb | DNA Inhibitor | 100 | $ 1,250.00 | 0.5 |
| LEV-MSG1-500 | 500 | $ 4,500.00 | |||
| LEV-MSG2-100 | Mouse Anti-PBD SG3199 (8G2H12A9) mAb | DNA Inhibitor | 100 | $ 1,250.00 | 0.5 |
| LEV-MSG2-500 | 500 | $ 4,500.00 | |||
| LEV-MSG3-100 | Mouse Anti-PBD SG3199 (8B3D12G1) mAb | DNA Inhibitor | 100 | $ 1,250.00 | 0.5 |
| LEV-MSG3-500 | 500 | $ 4,500.00 |