ImmuSmol
Cinnabarinic acid antibody Cinnabarinic acid抗体
Ref: IS005
个也是仅有的一个经过验证的抗Cinnabarinic酸抗体可供研究使用。人脑和乳腺肿瘤组织中5C5-E10单克隆抗体的IHC验证显示,在特定细胞中存在朱砂酸,一种以其免疫调节作用而闻名的色氨酸代谢物。
克隆 |
单克隆抗体(克隆5C5-E10) |
主办 |
老鼠 |
有条件的申请 |
IHC |
物种反应性 |
与所有物种发生反应 |
格式 |
50μL |
通过IHC检测人乳腺肿瘤中的朱砂酸
人乳腺肿瘤组织的免疫组织化学染色显示在坏死区域周围的细胞中存在朱砂酸。将石蜡包埋的肿瘤组织进行pH = 6的抗原修复,然后与初级抗朱砂螨抗体(1/500稀释)孵育过夜。加入聚合物缀合的第二抗体,并使用DAB显示免疫染色。
产品概述
产品名称 |
Cinnabarinic acid抗体 |
同义词 |
2-氨基-3-氧代-3H-吩恶嗪-1,9-二羧酸抗体 |
免疫原 |
共轭的朱砂酸 |
同型 |
IgG1 k链 |
克隆 |
克隆5C5-E10 |
特异性 |
当在竞争性ELISA中测试时,抗朱砂酸抗体5C5-E10不与其前体3-OH-0氨基苯甲酸缀合物交叉反应。 |
批号 |
140201 |
存储
形成 |
液体 |
纯度 |
纯化的IgG |
浓度 |
0.5mg / ml |
存储 |
储存在4°C |
存储缓冲区 |
储存在+ 4°C短期(1-2周)。分装并在-20°C下长期保存。避免反复冻/融循环 |
材料安全数据表 |
下载MSDS |
协议
免疫组化(IHC) |
以1:200-1:2000稀释。在石蜡包埋和冷冻切片上开始IHC染色方案之前,进行热抗原修复(pH = 6) |
免疫荧光(IF) |
在石蜡包埋和冷冻切片上以1:100-1:1000稀释。进行热抗原修复并 与荧光二抗缀合物一起孵育。 |
注释 |
宜工作稀释度必须由终用户确定 |
限制 |
仅供研究使用 |
参考
关于朱砂酸的精选出版物:
- Fazio F,Zappulla C,Notartomaso S,Busceti C,Bessede A,Scarselli P,Vacca C,Gargaro M,Volpi C,Allegrucci M,Lionetto L,Simmaco M,Belladonna ML,Nicoletti F,Fallarino F. Cinnabarinic acid,anogenous 4型代谢型谷氨酸受体激动剂抑制小鼠实验性自身免疫性脑脊髓炎。神经药理学。2014年2月21日.pii:S0028-3908(14)00075-6。doi:10.1016 / j.neuropharm.2014.02.011。[提前打印]
- Lowe MM,Mold JE,Kanwar B,Huang Y,Louie A,Pollastri MP,Wang C,Patel G,Franks DG,Schlezinger J,Sherr DH,Silverstone AE,Hahn ME,McCune JM。鉴定作为新型内源性芳基烃受体配体的朱砂酸驱动IL-22产生。PLoS One。2014年2月3日; 9(2):e87877。doi:10.1371 / journal.pone.0087877。eCollection 2014。
- Fazio F,Lionetto L,Molinaro G,Bertrand HO,Acher F,Ngomba RT,Notartomaso S,Curini M,Rosati O,Scarselli P,Di Marco R,Battaglia G,Bruno V,Simmaco M,Pin JP,Nicoletti F,Goudet C.Cinnabarinic acid,一种犬尿氨酸途径的内源代谢产物,激活4型代谢型谷氨酸受体。Mol Pharmacol。2012年5月; 81(5):643-56。doi:10.1124 / mol.111.074765。Epub 2012年2月6日。
- Fukuyama K,Tanahashi S,Hoshikawa M,Shinagawa R,Okada M. Zonisamide通过星形胶质细胞犬尿氨酸途径调节基底神经节传递。神经药理学。2014年1月; 76 Pt A:137-45。doi:10.1016 / j.neuropharm.2013.08.002。Epub 2013年8月22日。
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