人类凝血因子Xa Human Factor Xa(HFXa 1011)说明书

 Enzyme Research ,Enzyme Research 介绍,Enzyme Research 代理,Enzyme Research 代理,Enzyme Research *代理,Enzyme Research 中国代理

Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。Enzyme Research通过不断追求产品的zui高品质,赢得了世界各地凝血研究实验室的信任。

Human Factor Xa

 

HFXa 1011             Human Factor Xa

Human Factor Xa is prepared from Human Factor X by activation with Russell’s Viper Venom. This RVV-X is removed after activation. Complete activation is observed by SDS-PAGE. Factor Xa along with cofactor Va, phospholipids and calcium ions, (the prothrombinase complex) catalyzes the rapid conversion of prothrombin to thrombin.

Buffer composition = 20 mM Bis Tris/0.7 M NaCl/pH 6.0
*Extinction Coefficient (1%) =11.6
One unit = 8 µg
Molecular Weight = 46,000 daltons

Also available: Human Factor Xaβ, des-Gla Xaβ and 
Xa inactivated

人凝血因子XIIIa(Human Factor XIIIa)HFXIIIa 1314说明书

 Enzyme Research ,Enzyme Research 介绍,Enzyme Research 代理,Enzyme Research 代理,Enzyme Research *代理,Enzyme Research 中国代理

Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。Enzyme Research通过不断追求产品的zui高品质,赢得了世界各地凝血研究实验室的信任。

Human Factor XIIIa

 

HFXIIIa 1314        Human Factor XIIIa

Human Factor XIII is cleaved with human alpha thrombin.  The thrombin is subsequently removed via chromatography.  The above protein was purified from Human plasma that was tested and found negative by FDA accepted methods fro Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, ABC ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA.  Donors are screened for CJD (Creutzfeldt-Jakob Disease). 

Buffer composition =  50 mM Tris/ 100 mM NaCl/ 1 mM EDTA/ 10 u/mL aprotinin/ 50 uM DTT/50% glycerol/ pH 7.5
*Extinction Coefficient (1%)=13.8
Molecular Weight = 312,000 daltons

 

人凝血因子Ⅶ(Human Factor VII) HFVII 1007 说明书

 Enzyme Research Laboratories为生物技术公司,制药行业、医院和大学的研究实验室提供用于的纯化抗凝因子。除了其制造能力,Enzyme Research Laboratories也创新研发领域中的血液凝固技术。

Enzyme Research的产品线包括:
从人类和牛等离子体纯化酶原激活酶
凝血因子的单克隆和多克隆抗体
检测凝血因子ELISA试剂
自定义的肽和蛋白质纯化服务

Human Factor VII

 

HFVII 1007              Human Factor VII (Proconvertin)

Prepared from fresh frozen human plasma. Human Factor VII is a single-chain vitamin K dependent glycoprotein found in trace quantities in plasma (0.5 mg/Liter). In the Tissue Factor Pathway of coagulation, Human Factor Vlla, in the presence of calcium ions and tissue factor, activates Factors IX and X to their enzymatically active forms, Factor IXa and Xa.

Buffer composition =20 mM Tris-HCl/0.1 M NaCl/1 mM Benzamidine/pH 7.4
*Extinction Coefficient (1%) = 13.9
Molecular Weight = 50,000 daltons

上海金畔生物科技有限公司

Bovine Factor V/Va 说明书

世界*实验材料供应商Enzyme research 上海金畔生物为其中国代理,Enzyme research在一直是行业的*,一直为广大科研客户提供zui为的产品和服务,上海金畔生物一直秉承为中国科研客户带来的产品,的服务,Enzyme research 就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获

Enzyme research 中国代理,Enzyme research上海代理,Enzyme research 北京代理,Enzyme research广东代理,Enzyme research 江苏代理Enzyme research 湖北代理,Enzyme research 天津,Enzyme research 黑龙江代理,Enzyme research 内蒙古代理,Enzyme research 吉林代理,Enzyme research 福建代理,Enzyme research 江苏代理,Enzyme research 浙江代理,Enzyme research 四川代理,

 

Enzyme Research Laboratories公司是一家致力于提供高纯度凝血因子相关产品的生物高科技公司,供应的产品包括纯化的人/牛血浆蛋白(包括多种凝血因子)、重组蛋白、Immune Depleted Plasmas、凝血/血栓研究相关抗体。产品广泛应用于生物技术、生物制药、医院及研究所的科研等众多领域。作为该领域的行业,Enzyme Research Laboratories在近十年间为止血及血栓症研究提供了的产品支持。除了成熟的产品线外,Enzyme Research Laboratories公司凭借多年的研发和鉴定经验,还提供蛋白/多肽测序、多肽合成、寡核苷酸合成、氨基酸谱分析等定制研究服务。

 

Bovine Factor V/Va

牛因子V / Va

目录号:  BFV / VA

尺寸:   1.0mg,5.0mg

使用盐沉淀和柱层析的组合从新鲜收集的牛血浆中纯化。该蛋白质是由4-20%梯度凝胶判定的因子V / Va和中间活化产物的混合物。牛因子Va作为与丝氨酸蛋白酶因子Xa在凝血酶原激活中的辅因子。该蛋白质可用作凝血酶原酶复合物中V / Va的来源。

缓冲液组成= 20mM HEPES-HCl / 0.15M NaCl / pH 7.4 / 50%甘油
消光系数(1%)= 9.6 / 17.4 
分子量= 33万; 94000; 74000; 71000; 31,000道尔顿
浓度由BCA确定

 

人纤维蛋白原Human Fibrinogen 2(Factor I)说明书

  Enzyme Research ,Enzyme Research 介绍,Enzyme Research 代理,Enzyme Research 代理,Enzyme Research *代理,Enzyme Research 中国代理

Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。

Human Fibrinogen (Factor I)

Human Fibrinogen

FIB 2 Plasminogen and von Willebrand Factor Depleted

 

Conversion of soluble fibrinogen to the insoluble fibrin is the final step in the blood coagulation cascade. ERL offers three types of purified fibrinogen prepared by a combination of salt precipitation, affinity chromatography and immunoaffinity chromatography methods to suit the individual researcher’s needs. All three forms are >95% clottable (by functional assays) and purity is >95% by SDS-PAGE.

 

  • FIB 1 Plasminogen Depleted
  • FIB 2 Plasminogen and von Willebrand Factor Depleted
  • FIB 3 Plasminogen, von Willebrand Factor and Fibronectin Depleted

 

Buffer composition = 20 mM Sodium Citrate-HCl/pH 7.4
*Extinction Coefficient (1%) = 15.1
Molecular Weight = 330,000 daltons

 

 

Factor V产品目录

 

Factor V

(化】 因子V; 凝血因子V; 第五因子; 凝血第五因子; 促凝血球蛋白原; 前加速因子
【医】 [凝血]第五因子, 前加速因子, 第五因子, 磷酸吡啶核甙酸

凝血因子是参与血液凝固过程的各种蛋白质组分。它的生理作用是,在血管出血时被激活,和血小板粘连在一起并且补塞血管上的漏口。这个过程被称为凝血。整个凝血过程大致上可分为两个阶段,凝血酶原的激活及凝胶状纤维蛋白的形成。它们部分由肝生成。可以为香豆素所抑制。为统一命名,世界卫生组织按其被发现的先后次序用罗马数字编号, 有凝血因子Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ,Ⅶ,Ⅷ,Ⅸ,Ⅹ,Ⅺ,Ⅻ,Xlll等,因子XIII以后被发现的凝血因子,经过多年验证,认为对于凝血功能,无决定性的影响,不再列入凝血因子的编号。因子 VI 事实上是活化的第五因子,已经取消因子VI的命名。

 

主要凝血因子

编辑

因子I,纤维蛋白原

因子II,凝血酶原(凝血素)

因子III,组织因子(凝血酶原酶)

因子IV,钙因子(Ca2+)

因子V,促凝血球蛋白原,易变因子

因子VII,转变加速因子前体,促凝血酶原激酶原,辅助促凝血酶原激酶

因子VIII,抗血友病球蛋白A(AHG A),抗血友病因子A(AHF A),血小板辅助因子I,血友病因子VIII或A

因子IX,抗血友病球蛋白B(AHG B),抗血友病因子B(AHF B),血友病因子IX或B

因子X,STUART(-PROWER)-F,自体凝血酶原C

因子XI,ROSENTHAL因子,抗血友病球蛋白C

因子XII,HAGEMAN因子,表面因子

因子XIII,血纤维稳定因子

 

 

 

Factor V产品目录

货号 品名 规格 价格 品牌
SAFV-IG Sheep anti  human Factor V  purified IgG 10 mg 2635 affinity
SAFV-HRP Sheep anti  human Factor V  peroxidase conjugated IgG 0.2 mg 4029 affinity
SAFV-APFTC Sheep anti  human Factor V  affinity purified, FITC conjugated IgG 0.1 mg 4029 affinity
SAFV-APBIO Sheep anti  human Factor V  affinity purified, Biotinylated IgG 0.1 mg 4029 affinity
SAFV-AP Sheep anti  human Factor V  affinity purified IgG 0.5 mg 6137 affinity
5134004 F V Deficient plasma, immund. 5×1 ml CE 4105.5 Technoclone
INH5-LDP human Factor V Inhibitor Plasma 1ml 494 affinity
INH5-DP human Factor V Inhibitor Plasma 1ml 430 affinity
FV-EIA Factor V 5 plates 6562 affinity
PF100511 Factor V, Human 50 ug 4980 AssayPro
CEF10052 Human Factor V ELISA Kit Low (Negative) Reference Plasma Control   1100 AssayPro
CEF10051 Human Factor V ELISA Kit High (Positive) Reference Plasma Control (calibrated against WHO reference standard)   900 AssayPro
CK071K HEMOCLOT Factor V Reagent 6 x 1 mL 780 hyphen
PAHFV-S Sheep anti-Human Factor V 1×1 mg 436.8 Haematologic
PAHFV-S Sheep anti-Human Factor V 1×5 mg 1506.96 Haematologic
PABFV-S Sheep anti-Bovine Factor V 1×1 mg 873.6 Haematologic
PABFV-S Sheep anti-Bovine Factor V 1×5 mg 3013.92 Haematologic
PAHFV-H Horse anti-Human Factor V 1×1 mg 873.6 Haematologic
PAHFV-H Horse anti-Human Factor V 1×5 mg 3013.92 Haematologic
11291-05021 Factor V, anti-human 150 ug 2800 AssayPro
11291-05011 Factor V, anti-human 150 ug 2320 AssayPro
AHV-5146 Anti-Human Factor V 1×100 µg 1179.36 Haematologic
AHV-5146 Anti-Human Factor V 5×100 µg 3057.6 Haematologic
AHV-5112 Anti-Human Factor V 1×100 µg 1179.36 Haematologic
AHV-5112 Anti-Human Factor V 5×100 µg 3057.6 Haematologic
AHV-5110 Anti-Human Factor V 1×100 µg 1179.36 Haematologic
AHV-5110 Anti-Human Factor V 5×100 µg 3057.6 Haematologic
AHV-5108 Anti-Human Factor V 1×100 µg 1179.36 Haematologic
AHV-5108 Anti-Human Factor V 5×100 µg 3057.6 Haematologic
AHV-5102 Anti-Human Factor V 1×100 µg 1179.36 Haematologic
AHV-5102 Anti-Human Factor V 5×100 µg 3057.6 Haematologic
AHV-5101 Anti-Human Factor V 1×100 µg 1179.36 Haematologic
AHV-5101 Anti-Human Factor V 5×100 µg 3057.6 Haematologic
SAFV-IG Anti-human F.V (F.V)sheep, purified IgG, 10 mg 2635 Enzyme Research
SAFV-HRP Anti-human F.V (F.V)sheep, perox-conj. IgG, 0.2 mg 4029 Enzyme Research
SAFV-APFTC Anti-human F.V (F.V)sheep, AP-FITC 0.1 mg 4029 Enzyme Research
SAFV-AP Anti-human F.V (F.V)sheep, affinity purified IgG, 0.5 mg 6137 Enzyme Research
ABX-5051 Anti-Bovine Factor X 1×100 µg 1179.36 Haematologic
ABX-5051 Anti-Bovine Factor X 5×100 µg 3057.6 Haematologic
ABV-5107 Anti-Bovine Factor V 1×100 µg 1179.36 Haematologic
ABV-5107 Anti-Bovine Factor V 5×100 µg 3057.6 Haematologic
ABV-5106 Anti-Bovine Factor V 1×100 µg 1179.36 Haematologic
ABV-5106 Anti-Bovine Factor V 5×100 µg 3057.6 Haematologic
ABV-5105 Anti-Bovine Factor V 1×100 µg 1179.36 Haematologic
ABV-5105 Anti-Bovine Factor V 5×100 µg 3057.6 Haematologic
ABV-5104 Anti-Bovine Factor V 1×100 µg 1179.36 Haematologic
ABV-5104 Anti-Bovine Factor V 5×100 µg 3057.6 Haematologic
ABV-5103 Anti-Bovine Factor V 1×100 µg 1179.36 Haematologic
ABV-5103 Anti-Bovine Factor V 5×100 µg 3057.6 Haematologic
SABFV-IG Anti-bovine F.V (F.V)sheep, purified IgG, 10 mg 2635 Enzyme Research
SABFV-AP Anti-bovine F.V (F.V)sheep, affinity purified IgG, 0.5 mg 4794 Enzyme Research
SABFV-HRP Anti-bovine F.V (F.V)sheep perox-conj. IgG, 0.2 mg 4029 Enzyme Research
ADG555 Russell's viper venom, factor V activating protein 1000 U 7875 ADI
HCV-0100 Human Factor V 1×50 µg 4476.5448 Haematologic
HCV-0100 Human Factor V 5×50 µg 20245.68 Haematologic
HCV-0100 Human Factor V 5×1 mg 358798.44 Haematologic
HCV-0100 Human Factor V 10×1 mg 706349.28 Haematologic
HCV-0100 Human Factor V 50×1 mg 3178571.76 Haematologic
HCV-0100 Human Factor V 100×1 mg 6213174.24 Haematologic
HCV-0100 Human Factor V 500×1 mg 27972781.2 Haematologic
ADG450 factor V, human 50 µg 11150 ADI
BFV/Va Bovine Factor V/Va 1 mg 3431.2392 Enzyme Research
BFV/Va Bovine Factor V/Va 5 mg 13636.5228 Enzyme Research
BCV-1100 Bovine Factor V 1×100 µg 4476.5448 Haematologic
BCV-1100 Bovine Factor V 5×100 µg 20245.68 Haematologic
BCV-1100 Bovine Factor V 5×1 mg 179511.696 Haematologic
BCV-1100 Bovine Factor V 10×1 mg 353624.544 Haematologic
BCV-1100 Bovine Factor V 50×1 mg 1590410.64 Haematologic
BCV-1100 Bovine Factor V 100×1 mg 3108836.64 Haematologic
BCV-1100 Bovine Factor V 500×1 mg 14003262 Haematologic
DP020K Factor V Deficient Plasma 6 x 1 mL 2000 hyphen
ADG205 factor V deficient human plasma 10×1 mL 2500 ADI
FV-ID Factor V deficient 176x1mL 10560 Haematologic
RK009A ZYMUTEST Factor V Kit of 96 tests 8010 hyphen
EF1005-1 Human Factor V ELISA Kit 96 well plate 4760 AssayPro
Factor V Factor V elisa kit 5 plate  6562 Enzyme Research
FV-DP human Factor V * deficient plasma 1ml 123 affinity
         
SC065K Factor V-L calibrator 4x3x1 mL 825 hyphen
CK061L HEMOCLOT Factor V-L Kit 2760 hyphen
CK061K HEMOCLOT Factor V-L Kit 4515 hyphen

人凝血因子Human Factor XII (HFXII 1212)说明书

 Enzyme Research ,Enzyme Research 介绍,Enzyme Research 代理,Enzyme Research 代理,Enzyme Research *代理,Enzyme Research 中国代理

Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。Enzyme Research通过不断追求产品的zui高品质,赢得了世界各地凝血研究实验室的信任。
Enzyme Research Laboratories为生物技术公司,制药行业、医院和大学的研究实验室提供用于的纯化抗凝因子。除了其制造能力,Enzyme Research Laboratories也创新研发领域中的血液凝固技术。

Human Factor XII

 

HFXII 1212         Human Factor XII (Hageman Factor)

Purified from fresh frozen human plasma. Human Factor XII is part of the contact activation system. Human Factor XII is a single chain glycoprotein with a molecular weight of about 80,000. Once activated, principally from the action of kallikrein, Factor XII is converted into an active serine protease (Factor α-Xlla) that functions in the in vivo initiation of blood coagulation, fibrinolysis, and kinin formation. Human Factor XII has been purified by ion exchange chromatography. Protein purity is determined by SDS-PAGE and activity is determined via clotting assay.

Buffer composition = 4 mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3 
*Extinction Coefficient (1%) =14.1
Molecular Weight = 80,000 daltons

人凝血因子XIa(Human Factor XIa)HFXIa 1111a 说明书

 Enzyme Research ,Enzyme Research 介绍,Enzyme Research 代理,Enzyme Research 代理,Enzyme Research *代理,Enzyme Research 中国代理

Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。Enzyme Research通过不断追求产品的zui高品质,赢得了世界各地凝血研究实验室的信任。

Human Factor XIa

 

HFXIa 1111a             Human Factor XIa

Prepared from Human Factor XI using Human Factor Xlla. This Xlla was removed using a corn trypsin inhibitor column. Complete activation is observed by SDS-PAGE. Factor XI, through the contact factor pathway cascade, is activated to Factor XIa via Factor Xlla and High Molecular Weight Kininogen. During activation by Factor Xlla and HK, FXI undergoes proteolytic cleavage in which the Mr=80,000 chain reportedly is cleaved to a heavy and light chain with Mr of about 48,000 and 33,000. This Factor XIa is responsible for the activation of Factor IX to Factor IXa. Unlike other examples of activation of Vitamin K-dependent blood-clotting proteins, Factor XIa proteolysis of Factor IX does not require membrane surfaces.

Buffer composition = 4 mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3
*Extinction Coefficient (1%) = 13.1
Molecular Weight = 160,000 daltons

affinitybiologicals Factor VIII说明书

Affinity Biologicals,Inc。是血栓形成和止血研究和诊断中使用的产品的主要制造商。我们的产品包括广泛的抗体,结合物,用于人和动物分析物免疫分析的抗体对,VisuLize完整ELISA试剂盒系列,以及包括VisuDep免疫缺​​陷因子缺陷等离子体在内的全系列人血浆产品,VisuCal Calibrator Plasma和VisuCon控制等离子体。服务包括蛋白质纯化,抗体生产,化验开发,定制生产,包括定制冻干和能力验证材料。

affinitybiologicals Factor VIII说明书

Factor VIII ELISA Kit说明书

 FVIII-AG-RUO 人八因子抗原ELISA试剂盒 VisuLize FVIII Antigen ELISA Kit 

因子VIII ELISA试剂盒

FVIII-AG – 完整因子VIII抗原ELISA试剂盒 – 1个板/试剂盒

类别:因子VIII:C抗原ELISA试剂盒,抗体,ELISA试剂盒,Factor VIII产品,Factor VIII抗体

 

 

因子VIII ELISA试剂盒

VisuLize Factor VIII ELISA试剂盒旨在定量测量人血浆和因子浓缩物中的因子VIII(F8)。在血友病A和疑似血栓形成倾向的患者中证实了因子VIII(F8)的生物学重要性。血友病A中因子VIII(F8)缺乏的实验室诊断通常涉及因子VIII的功能活性的定量测定。将该试剂盒与基因治疗领域的功能测定结合使用,评估因子VIII(F8)浓缩物,以及区分这些患有交叉反应物质的患者将证明在血友病A领域是有用的。在许多研究中,因子VIII(F8)水平升高被认为是静脉血栓形成的常见风险¹,

该产品 经FDA,加拿大卫生部和CE标记体外诊断使用。可在美国,加拿大和部分欧洲国家/地区销售。

产品代码: FVIII-AG

特征:

  • 快速夹心ELISA测定FVIII(F8)抗原(FVIII:Ag)
  • 总孵化时间为1小时55分钟!
  • FVIII:Ag报告为可追溯至WHO标准的FVIII抗原的单位/ ml
  • 检出限为0.008 IU / ml FVIII:Ag(0.8%)
  • 包括正常和低控制
  • 保质期:18个月

应用:

  • 血浆和治疗浓缩物中FVIII(F8)的定量
  • 血友病A的诊断和特征
  • 血友病A的载体检测
  • 血栓形成筛查

参考文献: 1.O'Donnell J,Tuddenham EG,Manning R,Kemball-Cook G,Johnson D,Laffan M.血栓形成倾向筛查患者中升高因子VIII水平的高患病率:合成增加的作用和与急性期的关系反应。Thromb Haemost。1997; 77:825-828。

 

因子VIII(FVIII)的描述

因子VIII(以前称为抗血友病球蛋白和因子VIII:C)是大的糖蛋白(320kDa),其在血浆中以约200ng / ml循环。在肝脏中合成,大部分因子VIII在表达过程中被切割,产生大小为200-280kDa的部分切割形式的FVIII的异质混合物。通过与冯维勒布兰德因子结合来稳定FVIII,以形成体内FVIII正常存活所需的FVIII-vWF复合物(t1 / 2为8-12小时)。

F.VIII是一种促辅因子,其通过凝血酶的有限蛋白水解而被激活。在该过程中,F.VIIIa与vWF解离以与活化的因子IX,钙和磷脂表面结合,其中它是因子X活化剂复合物的组装中的必需辅因子。一旦与vWF解离,FVIIIa易被活化的蛋白C失活和非酶促衰变。

血友病A是由X染色体相关的FVIII缺乏引起的先天性出血性疾病。缺陷的严重程度通常与疾病的严重程度相关。一些血友病患者(~10%)产生部分或*无活性的FVIII蛋白。FVIII中和抗体的产生也发生在5-20%的血友病患者1-3

 

Bovine Factor IX(牛凝血因子IX)BFIX 1005 说明书

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Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。

Bovine Factor IX

 

 

 

BFIX 1005                    Bovine Factor IX

 

Prepared from freshly collected bovine plasma. Protein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. Activated Factor IX via factor Xla or the factor VIIa/tissue factor/phospholipid complex, 
is responsible for the activation of Factor X to Xa.

Buffer composition = 20 mM Tris-HCl/0.1 M NaCl/1 mM Benzamidine/pH 7.4
*Extinction Coefficient (1%) = 14.9
One unit = 5 µg
Molecular Weight = 55,400 daltons