Moradec Fab-αHFc-NC-MMAF说明书

 

Moradec LLC由Helen(Hongyuan)Mao博士于2012年创立,主要目标是为快速和经济的抗体 – 药物结合物发现提供新颖的研究工具。毛博士拥有超过14年的工业研发经验,包括主要制药公司,中小型生物技术公司。她近担任Fabrus的科学官,这是开发Fabrus Arrayed抗体筛选技术的关键。除了广泛的抗体优化专业知识外,她还积累了基于表皮生长因子受体的抗体治疗方法的丰富知识。在Fabrus之前,Mao博士领导了Biosite(现为Alere)抗体开发的蛋白质纯化组,先进的诊断公司,拥有用于开发诊断抗体的噬菌体展示平台技术。在Ansata Therapeutics,毛博士发明了基于分选酶的新型酶促蛋白质结合方法,该方法已经获得了研究应用,用于细胞表面标记,蛋白质阵列,核磁共振和蛋白质 – 药物结合等。毛医生进行了她的博士后诺华研究基金会(GNF)雅培实验室和基因组研究所的研究。她在麻省理工学院获得生物化学博士学位,在北京大学获得化学学士学位。毛在诺华研究基金会(GNF)的雅培实验室和基因组研究所进行了博士后研究。她在麻省理工学院获得生物化学博士学位,在北京大学获得化学学士学位。毛在诺华研究基金会(GNF)的雅培实验室和基因组研究所进行了博士后研究。她在麻省理工学院获得生物化学博士学位,在北京大学获得化学学士学位。

Moradec Fab-αHFc-NC-MMAF说明书

Fab-αHFc-NC-MMAF

FAB-αHFc-NC-MMAF

具有不可切割接头的Fab抗人IgG Fc-MMAF抗体

目录编号:AH-201-AF

Fab-αHFc-NC-MMAF是与具有不可切割接头的单甲基auristatin F(MMAF)缀合的抗人IgG Fc特异性抗体的Fab片段。抗体部分是对人IgG的Fc区特异的多克隆抗体Fab片段。单甲基auristatin F(MMAF)是一种细胞毒性小分子,通过阻断微管蛋白的聚合来抑制细胞分裂。连接MMAF与抗体的不可切割接头在细胞外液中是稳定的,但是在进入细胞时可以通过未的机制切割。Fab 2°ADC的单价性质在某些应用中可能比全长IgG 2°ADC具有一些优势。

 

 

二抗 – 药物偶联物目录

Moradec的新型二抗 – 药物偶联物(2°ADC)是预先筛选抗体导联作为ADC候选物的重要研究工具。“他们工作非常出色,而且没有主要的ab,它们的毒性极低!

 

 

具有可切割接头的IgGs抗人IgG Fc-PBD抗体

具有可切割接头的IgGs抗小鼠IgG Fc-PBD抗体

具有可切割接头的IgG抗兔IgG(H + L)-PBD抗体

Anti-Human IgG (Fc Specific)

IgGs Anti-Human IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αHFc-NC-MMAF

IgGs Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker

AH-101AF-50

50µg

$330

AH-101AF-20

20µg

$165

αHFc-CL-MMAF

IgGs Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker

AH-102AF-50

50µg

$330

AH-102AF-20

20µg

$165

αHFc-CL-MMAE

IgGs Anti-Human IgG Fc-MMAE Antibody with Cleavable Linker

AH-102AE-50

50µg

$330

AH-102AE-20

20µg

$165

αHFc-CL-DMSA

IgGs Anti-Human IgG Fc-Duocarmycin SA Antibody with Cleavable Linker

AH-102DS-50

50µg

$330

AH-102DS-20

20µg

$165

αHFc-CL-DMDM

IgGs Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

AH-102DD-50

50µg

$330

AH-102DD-20

20µg

$165

αHFc-CL-PNU

IgGs Anti-Human IgG Fc-PNU159682 Antibody with Cleavable Linker

AH-102PN-50

50µg

$330

AH-102PN-20

20µg

$165

αHFc-NC-DM1

IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker

AH-103D1-50

50µg

$330

AH-103D1-20

20µg

$165

αHFc-CL-PBD

IgGs Anti-Human IgG Fc-PBD Antibody with Cleavable Linker

AH-106PB-50

50µg

$330

AH-106PB-20

20µg

$165

 

Fab Fragments of Anti-Human IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αHFc-NC-MMAF

Fab Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker

AH-201AF-50

50µg

$440

AH-201AF-20

20µg

$220

Fab-αHFc-CL-MMAF

Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker

AH-202AF-50

50µg

$440

AH-202AF-20

20µg

$220

Fab-αHFc-CL-MMAE

Fab Anti-Human IgG Fc-MMAE Antibody with Cleavable Linker

AH-202AE-50

50µg

$440

AH-202AE-20

20µg

$220

Fab-αHFc-CL-DMSA

Fab Anti-Human IgG Fc-Duocarmycin SA Antibody with Cleavable Linker

AH-202DS-50

50µg

$440

AH-202DS-20

20µg

$220

Fab-αHFc-CL-DMDM

Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

AH-202DD-50

50µg

$440

AH-202DD-20

20µg

$220

Fab-αHFc-CL-PNU

Fab Anti-Human IgG Fc-PNU159682 Antibody with Cleavable Linker

AH-202PN-50

50µg

$440

AH-202PN-20

20µg

$220

Fab-αHFc-NC-DM1

Fab Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker

AH-203D1-50

50µg

$440

AH-203D1-20

20µg

$220

Fab-αHFc-NC-AAMT

Fab Anti-Human IgG Fc-Amanitin Antibody with Non-Cleavable Linker

AH-20M-50

50µg

$440

AH-20M-20

20µg

$220

 

Anti-Human IgG (Fab Specific)

IgGs Anti-Human IgG (Fab Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αHFab-NC-MMAF

IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker

AH-121AF-50

50µg

$360

AH-121AF-20

20µg

$180

αHFab-CL-MMAF

IgGs Anti-Human IgG Fab-MMAF Antibody with Cleavable Linker

AH-122AF-50

50µg

$360

AH-122AF-20

20µg

$180

αHFab-CL-MMAE

IgGs Anti-Human IgG Fab-MMAE Antibody with Cleavable Linker

AH-122AE-50

50µg

$360

AH-122AE-20

20µg

$180

αHFab-NC-DM1

IgGs Anti-Human IgG Fab-DM1 Antibody with Non-Cleavable Linker

AH-123D1-50

50µg

$360

AH-123D1-20

20µg

$180

 

Anti-Mouse IgG (Fc Specific)

IgGs Anti-Mouse IgG (Fc specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αMFc-NC-MMAF

IgGs Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker

AM-101AF-50

50µg

$374

AM-101AF-20

20µg

$187

αMFc-CL-MMAF

IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker

AM-102AF-50

50µg

$374

AM-102AF-20

20µg

$187

αMFc-CL-MMAE

IgGs Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker

AM-102AE-50

50µg

$374

AM-102AE-20

20µg

$187

αMFc-CL-DMSA

IgGs Anti-Mouse IgG Fc-Duocarmycin SA Antibody with Cleavable Linker

AM-102DS-50

50µg

$374

AM-102DS-20

20µg

$187

αMFc-CL-DMDM

IgGs Anti-Mouse IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

AM-102DD-50

50µg

$374

AM-102DD-20

20µg

$187

αMFc-CL-PNU

IgGs Anti-Mouse IgG Fc-PNU159682 Antibody with Cleavable Linker

AM-102PN-50

50µg

$374

AM-102PN-20

20µg

$187

αMFc-NC-DM1

IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker

AM-103D1-50

50µg

$374

AM-103D1-20

20µg

$187

αMFc-CL-PBD

IgGs Anti-Mouse IgG Fc-PBD Antibody with Cleavable Linker

AM-106PB-50

50µg

$374

AM-106PB-20

20µg

$187

Fab Fragments of Anti-Mouse IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αMFc-NC-MMAF

Fab Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker

AM-201AF-50

50µg

$495

AM-201AF-20

20µg

$248

Fab-αMFc-CL-MMAF

Fab Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker

AM-202AF-50

50µg

$495

AM-202AF-20

20µg

$248

Fab-αMFc-CL-MMAE

Fab Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker

AM-202AE-50

50µg

$495

AM-202AE-20

20µg

$248

Fab-αMFc-CL-DMDM

Fab Anti-Mouse IgG Fc-duocarmycin DM Antibody with Cleavable Linker

AM-202DD-50

50µg

$495

AM-202DD-20

20µg

$248

Fab-αMFc-NC-DM1

Fab Anti-Mouse IgG Fc-DM1 Antibody with Noncleavable Linker

AM-203D1-50

50µg

$495

AM-203D1-20

20µg

$248

 

Anti-Rabbit IgG (Fc Specific)

IgGs Anti-Rabbit IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αOFc-NC-MMAF

IgGs Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker

AO-101AF-50

50µg

$396

AO-101AF-20

20µg

$198

Fab Fragments of Anti-Rabbit IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αOFc-NC-MMAF

Fab Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker

AO-201AF-50

50µg

$528

AO-201AF-20

20µg

$264

 

Anti-Rabbit IgG(H+L)

IgGs Anti-Rabbit IgG (H+L) ADCs

Product Name

Description

Catalog No

QTY

Price

αOIgG-NC-MMAF

IgGs Anti-Rabbit IgG(H+L)-MMAF Antibody with Non-Cleavable Linker

AO-111AF-50

50µg

$396

AO-111AF-20

20µg

$198

αOIgG-CL-MMAF

IgGs Anti-Rabbit IgG(H+L)-MMAF Antibody with Cleavable Linker

AO-112AF-50

50µg

$396

AO-112AF-20

20µg

$198

αOIgG-CL-MMAE

IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker

AO-112AE-50

50µg

$396

AO-112AE-20

20µg

$198

αOIgG-CL-PBD

IgGs Anti-Rabbit IgG(H+L)-PBD Antibody with Cleavable Linker

AO-116PB-50

50µg

$396

AO-116PB-20

20µg

$198

Fab Fragments of Anti-Rabbit IgG (H+L) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αOIgG-NC-MMAF

Fab Anti-Rabbit IgG(H+L)-MMAF Antibody with Non-Cleavable Linker

AO-211AF-50

50µg

$528

AO-211AF-20

20µg

$264

Fab-αOIgG-CL-MMAF

Fab Anti-Rabbit IgG(H+L)-MMAF Antibody with Cleavable Linker

AO-212AF-50

50µg

$528

AO-212AF-20

20µg

$264

 

Anti-Rat IgG(Fc Specific)

IgGs Anti-Rat IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αRFc-NC-MMAF

IgGs Anti-Rat IgG Fc-MMAF Antibody with Non-Cleavable Linker

AR-101AF-50

50µg

$396

AR-101AF-20

20µg

$198

αRFc-CL-MMAF

IgGs Anti-Rat IgG Fc-MMAF Antibody with Cleavable Linker

AR-102AF-50

50µg

$396

AR-102AF-20

20µg

$198

Fab Fragments of Anti-Rat IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αRFc-NC-MMAF

Fab Anti-Rat IgG Fc-MMAF Antibody with Non-Cleavable Linker

AR-201AF-50

50µg

$528

AR-201AF-20

20µg

$264

Fab-αRFc-CL-MMAF

Fab Anti-Rat IgG Fc-MMAF Antibody with Cleavable Linker

AR-202AF-50

50µg

$528

AR-202AF-20

20µg

$264

Fab-αRFc-CL-MMAE

Fab Anti-Rat IgG Fc-MMAE Antibody with Cleavable Linker

AR-202AE-50

50µg

$528

AR-202AE-20

20µg

$264

Fab-αRFc-CL-DMDM

Fab Anti-Rat IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

AR-202DD-50

50µg

$528

AR-202DD-20

20µg

$264

 

Anti-Rat IgG(H+L)

IgGs Anti-Rat IgG (H+L) ADCs

Product Name

Description

Catalog No

QTY

Price

αRIgG-NC-MMAF

IgGs Anti-Rat IgG(H+L)-MMAF Antibody with Non-Cleavable Linker

AR-111AF-50

50µg

$396

AR-111AF-20

20µg

$198

Fab Fragments of Anti-Rat IgG (H+L) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αRIgG-NC-MMAF

Fab Anti-Rat IgG(H+L)-MMAF Antibody with Non-Cleavable Linker

AR-211AF-50

50µg

$528

AR-211AF-20

20µg

$264

Fab-αRIgG-CL-MMAF

Fab Anti-Rat IgG(H+L)-MMAF Antibody with Cleavable Linker

AR-212AF-50

50µg

$528

AR-212AF-20

20µg

$264

 

 

 

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上海金畔生物科技有限公司是实验试剂一站式采购服务商

1:强大的进口辐射能力,血清、抗体、耗材、大部分限制进口品等。

2:产品种类齐全,经营超过700多个品牌,基本涵盖所有生物实验试剂耗材。

3:提供加急服务,货品一般1-2周到货。

4:富有竞争力的价格优势,绝大部分价格有优势。

5:多年积累良好的信誉,大部分客户提供货到付款服务。客户包括清华、北大、交大、复旦、中山等100多所高校,ROCHE,阿斯利康、国药、fisher等药企。

6:我们还是Santa,Advanced Biotechnologies Inc,Athens Research & Technology,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, Genebridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,omicronbio, Polysciences,prospecbi, QA-BIO,quickzyme,RESEARCH DIETS,INC,sterlitech;sysy,TriLink BioTechnologies,Inc;worthington-biochem,zyagen等几十家国外公司代理。

7:我们还是invitrogen,qiagen,MiraiBioam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等*批发,欢迎合作。

 

ATS Bio Fab-pHast human 说明书

世界*实验材料供应商 Advanced Targeting Systems 上海金畔生物为其中国代理, Advanced Targeting Systems 在一直是行业的*,一直为广大科研客户提供zui为的产品和服务,上海金畔生物一直秉承为中国科研客户带来的产品,的服务, Advanced Targeting Systems 就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获

Advanced Targeting Systems 中国代理Advanced Targeting Systems 上海代理, Advanced Targeting Systems 北京代理,Advanced Targeting Systems 广东代理, Advanced Targeting Systems 江苏代理Advanced Targeting Systems 湖北代理,Advanced Targeting Systems 天津,Advanced Targeting Systems 黑龙江代理,Advanced Targeting Systems 内蒙古代理,Advanced Targeting Systems 吉林代理,Advanced Targeting Systems 福建代理, Advanced Targeting Systems 江苏代理, Advanced Targeting Systems 浙江代理, Advanced Targeting Systems 四川代理,

 

Advanced Targeting Systems (ATS)是一家位于圣地亚哥的生物技术公司,致力于为科学研究和药物开发提供高质量的靶向试剂。

ATS被称为“saporin人”,zui初专注于为神经科学研究界提供研究工具。多年来,这些工具已被用于科学研究和药物开发的所有领域。公司目前的产品线包括有针对性的毒素,抗体和定制服务,旨在帮助科学家研究系统功能,细胞功能,疾病和紊乱。

Advanced Targeting Systems 开创性地使用靶向缀合物用于称为“分子手术”的技术。这些产品包括用于胆碱能基底前脑神经元,去甲肾上腺素能和肾上腺素能神经元,巨噬细胞和小神经胶质细胞的特定损伤剂以及击打表位的泛神经元药剂在所有神经元上表达。另外,ATS销售“二次结合物”,允许用户将他们自己的靶向剂转化为特定的细胞毒性工具并筛选抗体进行内化。

先进的瞄准系统于1994年4月成立,以商业化并提供由Douglas Lappi博士开发和完善的Saporin技术平台。(名誉理事长,科学家)。Lappi博士与Ronald Wiley医学博士合作 (联合创始人)在他们的学术实验室验证使用总理皂草素共轭物,192-IgG-SAP建立阿尔茨海默病模型。Denise Higgins(联合创始人兼总裁)将她的业务专长和销售/营销经验带到了团队中,并继续致力于将这一创新技术带给的科学家。

 

Fab-pHast human [PH-01]

规格:100 ug, 250 ug, 1000 ug

 

在一(1)天内测试抗体特异性,结合和内在化的工具

 

描述

Fab-pHast人类是我们定量检测一抗的特异性,结合和内化的zui快工具之一,在1天内就可以提供结果。Fab-pHast人类通过与pH依赖性荧光报道分子交联的第二抗体与您的主要人类抗体结合。当暴露于细胞内的环境中时,这种荧光记者将增加强度,因为其周围的pH变得更酸性。成功的测定将通过荧光检测平板读数器提供EC50,照亮您的主要抗体候选物。

Fab-pHast人产生定量检测您的主要人类抗体的特异性,结合性和内在化,结果为1天。该二级结合物用于评估一级抗体内化的可能性。

 

与192-IgG缀合的Fab-pHast小鼠的荧光图像将以
p75神经营养因子受体转染的HEK-293细胞以20,000个细胞/孔接种在96孔板中并使其粘附过夜。在室温下,将10nM的192-IgG抗体(目录号AB-N43)与30nM的Fab-pHast小鼠(Cat.PH-02)一起温育20分钟。然后将Fab-pHast缀合的抗体加入到细胞中并在平板混合器上轻轻混合2分钟。将细胞孵育过夜以允许内化,尽管在几个小时内可检测到内化。用PBS替换培养基以获得更高的灵敏度,然后使用Y3 Leica过滤器立方体在放大倍数为20X的荧光显微镜下分析细胞。
*这个数据是使用Fab-pHast Mouse,Cat。#PH-02。我们预测Fab-pHast Human,Cat。#PH-01,表现相似。

 

pHast Ab内化测定将
亲本HEK-293细胞和用p75受体转染的HEK-293细胞铺在96孔板中过夜。滴加的192-IgG抗体(目录AB-N43)在室温下与50nM的Fab-pHast小鼠(Cat.PH -02)孵育20分钟,然后加入到细胞中。将平板温育过夜以允许zui大化内化,但几个小时就足以用于检测。在Spectra Max Gemini EM(例如:532nm / Em:560nm)上读板。数据分析由PRISM(GraphPad,San Diego)完成。

 

Rubber Fab 特约代理


Rubber Fab 特约代理

简要描述:Rubber Fab代理,Rubber Fab上海代理,Rubber Fab北京代理, Rubber Fab代理, Rubber Fab一级代理, Rubber Fab 特约代理
上海金畔生物科技有限公司 Rubber Fab专业代理,具体产品信息欢迎电询:021-50837765

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世界*实验材料供应商 Rubber Fab 上海金畔生物为其中国代理, Rubber Fab 在一直是行业的*,一直为广大科研客户提供zui为优质的产品和服务,上海金畔生物一直秉承为中国科研客户带来的产品,的服务, Rubber Fab 就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获

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公司:www.rubberfab.com

 

Rubber Fab Technologies Group was founded in 1995 by Robert DuPont, Sr. and Patrick Parisi (former owners of Sani-Tech®) in a farm house in Andover, NJ and the hose shop was in a barn on the property. Their first product that went to market was the Smart Gasket® and the business has been growing ever since! 

In 2008 Rubber Fab outgrew the Andover property where they started and went looking for a new place to house their growing business, their expanding hose shop and their massive gasket inventory. They found a suitable building in Sparta, NJ. Now, 8 years later, Rubber Fab has taken over the whole building. They have expanded the business to include an o-ring division, a clean room for product testing and more room for creating new & innovative products.

Rubber Fab is the leading innovator of high quality sanitary gaskets, hose, hose assemblies, tubing, pump, and filler machine components in a wide range of high purity and metal detectable/x-ray inspectable elastomeric materials. Rubber Fab’s metal detectable/x-ray inspectable products have been specifically designed to meet the guidelines set forth by the Food Safety Modernization Act.

They manufacture, market, and sell specialized trademarked products such as Tuf-Steel®, Tuf-Flex®, Torque-Rite®, Smart Gasket®, Detectomer®, ADI Free®, Smart Clamp™, and Smart Port™. Rubber Fab provide state of the art technology for the Biopharmaceutical, Food & Beverage, Dairy, and Industrial industries.

 

 

上海金畔生物科技有限公司