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•  
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​​Cynomolgus BCA-1/ BLC/ CXCL13 Protein (His Tag)

• Catalog: 10808-C02E

Please Choose:Application

Antibody Production; ELISA; Protein Array; Western Blot;

Size   1mg 

     50μg

Cynomolgus BCA-1/ BLC/ CXCL13 Protein (His Tag)

For Research Use Only

Synonym : 

BCA-1, BLC, CXCL13, C-X-C Motif Chemokine 13

Source:

Recombinant Cynomolgus BCA-1/ BLC/ CXCL13 Protein, Val 23 – Pro 109(NP_001028052.1) was expressed in E.coli cells.

Molecular Characterization:

Recombinant Cynomolgus BCA-1/ BLC/ CXCL13 Protein, with a 6*His tag at the N-terminus, consists of 103 amino acids and has a calculated molecular mass of 12.4 kDa. The apparent molecular mass of Recombinant Cynomolgus BCA-1/ BLC/ CXCL13 Protein is approximay 14 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Sequence:

Cynomolgus BCA-1/ BLC/ CXCL13 Protein (His Tag)

Endotoxin:

<1.0 EU per μg of the Recombinant Cynomolgus BCA-1/ BLC/ CXCL13 Protein by the LAL method.

Purity:

>90% as determined by SDS-PAGE.

SDS-PAGE:

Formulation:

Lyophilized from sterile 10 mM Tris, 250mM  NaCl, pH 8.0

Normally 5 % – 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Contact us for customized product format or formulation.

Storage:

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:

• 4-8℃ for 1 year in lyophilized state

• 4-8℃ for 1 month under sterile conditions after reconstitution

• -20℃ to -70℃ for 3 months under sterile conditions after reconstitution

Reconstitution:

Reconstitution instruction will be sent along with the products. Please refer to it for detailed information.

Background:

Cynomolgus CXCL13, also known as BCA-1 ( B-cell-attracting chemokine-1 ) or BLC ( B-lymphocyte chemoattractant ), is a major regulator of B-cell trafficking. BCA-1/ BLC/ CXCL13 Protein is a small cytokine belonging to the CXC chemokine family. BCA-1/ BLC/ CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. BCA-1/ BLC/ CXCL13 Protein is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. The increased level of BCA-1/ BLC/ CXCL13 Protein is a feature of systemic lupus erythematosus (SLE) that correlates with disease activity. Furthermore, BCA-1/ BLC/ CXCL13 Protein might be a readily available surrogate marker to monitor the extent of aberrant B-cell (dys-)function. The vascular endothelial BCA-1/ BLC/ CXCL13 Protein expression may be consequent to transcytosis. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1/ BLC/ CXCL13 Protein by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). BCA-1/ BLC/ CXCL13 Protein expression is a distinctive feature of angioimmunoblastic T-cell lymphoma, providing further support for the germinal center T-helper cell as the cell of origin for this neoplasm. Furthermore, BCA-1/ BLC/ CXCL13 Protein, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.