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英文版：Snake Venom Proteins
|
Activator
|
Source
|
Application
|
Remarks
|
|
|
|
|
113-01 / 113-04
|
Protac®
|
• Determination of protein C and protein S
• Protein C pathway assays
|
Serine protease Agkistrodon contortrix
|
|
116-01
|
Ecarin
|
• Prothrombin assay
• Determination of hirudin
|
Metalloprotease, activates specifically prothrombin via meizothrombin, does not need PL and Ca2+ Echis carinatus
|
|
119-02
|
Convulxin
|
Activation of human plaets via binding and clustering of GPVI-receptors under physiological conditions
|
Crotalus durissus
|
|
121-03
|
RVV Factor V-Activator
|
Activation of FV in APC-R assay
|
Serine protease, not inhibited by AT
|
|
121-06
|
RVV-X
|
• Determination of FX
• Screening assay for lupus anti-coagulants (diluted Russel viper venom test, dRVVT)
|
Metalloprotease, does also (weakly) activate protein C and factor IX Daboia (Vipera) russelli
|
|
800191
|
Pefakit® Reptilase® Time
|
Ready-to-use diagnostic reagent for measurement of
• functionality of fibrin poly-merisation
• afibrinogenemia or hypofibrinogen-emia
• hyperfibrinolysis
• thrombolytic therapy
|
CE-marked IVD Bothrops atrox
|
中文版：
蛇毒蛋白质
|
活化剂
|
资源
|
应用
|
备注
|
|
113-01 / 113-04
|
Protac®
|
•蛋白C和蛋白S的
测定•蛋白C途径测定
|
丝氨酸蛋白酶Agkistrodon contortrix
|
|
116-01
|
蝰蛇毒
|
•凝血酶原测定
•水蛭素测定
|
金属蛋白酶，通过凝血酶原特异性激活凝血酶原，不需要PL和Ca2 + Echis carinatus
|
|
119-02
|
惊厥
|
在生理条件下通过结合和聚集GPVI-受体激活人血小板
|
响尾蛇durissus
|
|
121-03
|
RVV因子V激动剂
|
在APC-R测定中激活FV
|
丝氨酸蛋白酶，不受AT抑制
|
|
121-06
|
RVV-X
|
•FX的测定
•狼疮抗凝剂的筛选测定（稀释的罗素毒蛇毒测试，dRVVT）
|
金属蛋白酶，也（弱）激活蛋白C和因子IX Daboia（Vipera）russelli
|
|
800191
|
Pefakit®Reptilase®时间
|
即用型诊断试剂，用于测量
纤维蛋白聚合物的功能
•纤维蛋白原血症或纤维蛋白原 – 肌原纤维•纤维蛋白
溶解
•溶栓治疗
|
CE标记的IVD Bothrops atrox
|
附件为113-01说明书。
Description: Protac, a single chain glycoprotein, is a fast-acting protein C activator isolated from the venom of the copperhead snake Agkistrodon contortrix and closely related snake species. This serine proteinase rapidly converts protein C of man and other vertebrates into activated protein C which may be determined either by measuring its prolonging effect on the activated partial thromboplastin time (APTT) or by measuring its enzyme activity by means of a specific
|
|
chromogenic substrate.
|
|
|
Application:
|
Determination of protein C and protein S levels.
|
|
Origin:
|
Agkistrodon contortrix snake venom
|
MW: 36’000 to 42’000
|
|
Assay:
|
Chromogenic method
|
Clotting method
|
|
|
0.050 ml human citrated plasma
|
0.025 ml human citrated plasma
|
|
|
0.050 ml Protac (0.5 unit/ml)
|
0.025 ml Protac (0.1 unit/ml)
|
|
|
=> incubate for 5 min at 37°C
|
0.025 ml Actin
|
|
|
0.800 ml 50 mM Tris-HCl buffer, pH 8.4
|
=> incubate for 4 min at 37°C
|
|
|
0.100 ml PefachromePCa (4 mM)
=> Determination of DOD/min at 405 nm
|
0.025 ml 25 mM CaCl2
=> Determination of clotting time
|
Unit definition: 1 Unit is the amount of Protac which activates the amount of protein C contained in 1 ml of normal citrated human plasma within 5 min at 37°C.
|
Stability:
|
Lyophilised vials:
Reconstituted vials:
|
5 years
30 days at 2 – 8°C, approx. 7 days at 37°C
|
|
|
|
1 year at -20°C, 1 month at 20°C.
|
Storage: May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2 – 8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.
References: Bastian S. Protein C-Diagnostik – Methoden, Interpretation und Limitationen. ellipse 2002; 18 (1): 11-16
Gempeler-Messina PM, Volz K, Bühler B, Müller C. Protein C Activators from Snake Venoms and Their Diagnostic Use. Haemostasis 2001; 31:266-72.
Robert A, Eschwege V, Hameg H, Drouet L, Aillaud MF. Anticoagulant response to Agkistrodon contortrix venom (ACV test): a new global test to screen for defects in the anticoagulant protein C pathway. Thromb Haemost 1996; 75: 562-66.
Kraus M, Noah M, Fickenscher K. The PCAT – a simple screening assay for assessing the functionality of the protein C anticoagulant pathway. Thromb Res 1995; 79: 217-22.
Meier J, Stocker K. Snake venom protein C activators. In: Handbook of Natural Toxins, Reptile Venoms and Toxins. Tu AT, ed. New York: Marcel Dekker 1990; 265-79.
Stocker K, Fischer H, Meier J, Brogli M, Svendsen L. Characterization of the protein C activator Protac from the venom of the southern copperhead (Agkistrodon contortrix) snake. Toxicon 1987; 25: 239-52.
|
Package size:
|
Vial containing 3 unit/vial Code:
|
113-01
|
|
|
Bulk [unit]
|
113-04
|
|
|
FOR RESEARCH USE ONLY. NOT FOR HUMAN USE OR DRUG USE.
|
|
Pentapharm 2018年产品列表
|
货号
|
品名
|
规格
|
目录价
|
品牌
|
|
081-01
|
Pefachrome® TH 5244
|
25 mg
|
3000.00
|
Pentapharm
|
|
081-05
|
Pefachrome® TH 5247
|
25 mg
|
3000.00
|
Pentapharm
|
|
081-09
|
Pefachrome® TH 5251
|
25 mg
|
3000.00
|
Pentapharm
|
|
081-11
|
Pefachrome® FXIIa/TH 5253
|
25 mg
|
3000.00
|
Pentapharm
|
|
081-45
|
Pefachrome® 6017
|
10 µmol
|
3000.00
|
Pentapharm
|
|
081-15
|
Pefachrome® TH 5256
|
25 mg
|
3000.00
|
Pentapharm
|
|
081-17
|
Pefachrome® TG
|
25 mg
|
3000.00
|
Pentapharm
|
|
081-66
|
Pefachrome® TH 8198
|
25 mg
|
3000.00
|
Pentapharm
|
|
082-33
|
Pefachrome® uPA 8294
|
25 mg
|
3000.00
|
Pentapharm
|
|
083-01
|
Pefachrome® PL/Tryp 5261
|
25 mg
|
3000.00
|
Pentapharm
|
|
083-02
|
Pefachrome® PL 5262
|
25 mg
|
3000.00
|
Pentapharm
|
|
083-03
|
Pefachrome® PL 5263
|
25 mg
|
3000.00
|
Pentapharm
|
|
083-04
|
Pefachrome® PL 5264
|
25 mg
|
3000.00
|
Pentapharm
|
|
084-01
|
Pefachrome® TRY 5274
|
25 mg
|
3000.00
|
Pentapharm
|
|
085-01
|
Pefachrome® FXa 5277
|
25 mg
|
3000.00
|
Pentapharm
|
|
085-03
|
Pefachrome® FXa 5279
|
25 mg
|
3000.00
|
Pentapharm
|
|
085-06
|
Pefachrome® FXa/LAL 5288
|
25 mg
|
3000.00
|
Pentapharm
|
|
086-11
|
Pefachrome® LAL 5288
|
100 μmol
|
6000.00
|
Pentapharm
|
|
085-27
|
Pefachrome® FXa 8595
|
25 mg
|
3000.00
|
Pentapharm
|
|
802050
|
Pefachrome® FXa 2732
|
25 mg
|
3000.00
|
Pentapharm
|
|
087-03
|
Pefachrome® C1E
|
25 mg
|
3000.00
|
Pentapharm
|
|
089-02
|
Pefachrome® PCa
|
25 mg
|
3000.00
|
Pentapharm
|
|
091-01
|
Pefachrome® tPA
|
25 mg
|
3000.00
|
Pentapharm
|
|
091-03
|
Pefachrome® tPA5312
|
25 mg
|
3000.00
|
Pentapharm
|
|
093-01
|
Pefachrome® FVIIa
|
25 mg
|
3000.00
|
Pentapharm
|
|
095-20
|
Pefachrome® FIXa
|
10 μmol
|
1500.00
|
Pentapharm
|
|
801058
|
Pefafluor® TH
|
25 mg
|
3600.00
|
Pentapharm
|
|
073-70
|
Aprotinin Conc. Solution (vial 50 ml)
|
Mio KIU
|
1500.00
|
Pentapharm
|
|
800277
|
Aprotinin Powder, lyoph. (vial 1 g)
|
Mio KIU
|
1200.00
|
Pentapharm
|
|
126-10
|
r-Hirudin EC
|
2000 ATU
|
3200.00
|
Pentapharm
|
|
381-01
|
Pefabloc® TH (α-NAPAP)
|
5 mg
|
1800.00
|
Pentapharm
|
|
399-01
|
Pefabloc® SC
|
1 g
|
2200.00
|
Pentapharm
|
|
399-01
|
Pefabloc® SC
|
10 g
|
20000.00
|
Pentapharm
|
|
099-01
|
Pefabloc® FG
|
1 g
|
11600.00
|
Pentapharm
|
|
099-11
|
Pefabloc® FG
|
50 mg
|
1200.00
|
Pentapharm
|
|
101-04
|
Batroxobin maranhao
|
100 BU
|
2500.00
|
Pentapharm
|
|
101-06
|
Batroxobin maranhao
|
1000 BU
|
22500.00
|
Pentapharm
|
|
113-01
|
Protac®
|
3 U
|
780.00
|
Pentapharm
|
|
113-05
|
Protac® solution 10 U/ml
|
1 ml
|
2400.00
|
Pentapharm
|
|
116-01
|
Ecarin
|
50 EU
|
1980.00
|
Pentapharm
|
|
119-02
|
Convulxin
|
50 µg
|
8600.00
|
Pentapharm
|
|
121-03
|
RVV-Factor V Activator
|
1000 U
|
6000.00
|
Pentapharm
|
|
121-06
|
RVV Factor X Activator
|
5 U
|
1000.00
|
Pentapharm
|
|
121-07
|
RVV-Factor X-Activator
|
50 U
|
6000.00
|
Pentapharm
|
|
502-01
|
Pefakit® APC-R Factor V Leiden 3 x 40 tests
|
Kit
|
3600.00
|
Pentapharm
|
|
502-21
|
Pefakit® APC-R Factor V Leiden Controls
|
Kit
|
1100.00
|
Pentapharm
|
|
505-01
|
Pefakit® PiCT®
|
Kit
|
4000.00
|
Pentapharm
|
|
505-22
|
Pefakit® PiCT® Controls UFH
|
Kit
|
3900.00
|
Pentapharm
|
|
800186
|
Pefakit® TAFI
|
Kit
|
10000.00
|
Pentapharm
|
|
800187
|
Pefakit® TAFI Controls and Calibration
|
Kit
|
6000.00
|
Pentapharm
|
|
800191
|
Pefakit® Reptilase® Time
|
Kit
|
2800.00
|
Pentapharm
|
|
069-03
|
Prionex® 10%
|
100 ml
|
2000.00
|
Pentapharm
|
|
069-03
|
Prionex® 10%
|
500 ml
|
9000.00
|
Pentapharm
|
|
069-03
|
Prionex® 10%
|
1000 ml
|
12000.00
|
Pentapharm
|
|
801682
|
Rabbit brain cephalin
|
100mg
|
12000.00
|
Pentapharm
|
上海金畔生物科技有限公司是实验试剂一站式采购服务商
1：强大的进口辐射能力，血清、抗体、耗材、大部分限制进口品等。
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3：提供加急服务，货品一般1-2周到货。
4：富有竞争力的价格优势，绝大部分价格有优势。
5：多年积累良好的信誉，大部分客户提供货到付款服务。客户包括清华、北大、交大、复旦、中山等100多所高校，ROCHE，阿斯利康、国药、fisher等药企。
6：我们还是Santa,Advanced Biotechnologies Inc,Athens Research & Technology,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, Genebridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,omicronbio, Polysciences,prospecbi, QA-BIO,quickzyme,RESEARCH DIETS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc；worthington-biochem,zyagen等几十家国外公司代理。
7：我们还是invitrogen,qiagen,MiraiBioam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等*批发，欢迎合作。
