L-NAME (eNOS抑制剂)(S0006)

L-NAME (eNOS抑制剂)

产品编号: S0006

产品包装:200mg
选择包装

200mg

说明书下载

137.00 10

价格: ¥ 137.00

产品简介
使用说明
产品图片
相关产品
相关论文
产品问答
产品编号 产品名称 产品包装 产品价格
S0006 L-NAME (eNOS抑制剂) 200mg 137.00元

L-NAME,即NG-Nitro-L-arginine Methyl Ester, Hydrochloride,也称L-NAME, HCl或N ω-NO2-L-Arg-OMe或NG
NO2-L-Arg-OMe,是eNOS(endothelial nitric oxide synthase)的可逆抑制剂,IC50=500nM。高浓度L-NAME(例如100μM或更高浓度)也可以显著抑制iNOS和nNOS。
L-NAME为接近白色的粉末,分子量269.7,分子式为C7H15N5O4·HCl,纯度大于98%。
溶解于水,可以配制成50mg/ml的水溶液。
包装清单:

产品编号 产品名称 包装
S0006 L-NAME(eNOS抑制剂) 200mg
说明书 1份

保存条件:
-20℃避光保存,一年有效。
注意事项:
如果配制成水溶液,分装后-20℃保存,4个月内有效。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。

使用说明:
1. L-NAME储备液的配制:称取少量L-NAME,推荐使用Milli-Q级纯水溶解L-NAME,使浓度为50mg/ml。
2. L-NAME的工作浓度通常为10-100μM。少数情况下浓度需达到500μM甚至5mM才可以观察到显著效果。其最佳工作浓度需根据具体的实验,自行摸索。可以先分别尝试10、30和100μM这三个浓度。如果效果不佳,可以尝试1μM等低浓度或300μM等更高浓度。

L-NAME (eNOS抑制剂)(S0006)

相关产品请点击如下按钮:
一氧化氮相关

使用本产品的文献:

1. Li XL, Zou XM, Gao P, Li YL, Wang H, Chen XW.
Role of nitric oxide in ischemia-reperfusion injury and acute rejection in rat intestinal transplantation.
TRANSPL P . 2008 Dec;40(10):3342-5. (IF 0.784)

2. Wang GF, Wu SY, Rao JJ, Lü L, Xu W, Pang JX, Liu ZQ, Wu SG, Zhang JJ.
Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells.
Acta Pharmacol Sin . 2009 May;30(5):589-96. (IF 5.064)

3. Zhong W, Zou G, Gu J, Zhang J.
L-arginine attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells.
Diabetes Res Clin Pract . 2010;89(1):38-45.

4. Li ZL, Liu JC, Liu SB, Li XQ, Yi DH, Zhao MG.
Improvement of vascular function by acute and chronic treatment with the GPR30 agonist G1 inexperimental diabetes mellitus.
PLoS One . 2012;7(6):e38787. (IF 2.74)

5. Zhang QH, Zu XY, Cao RX, Liu JH, Mo ZC, Zeng Y, Li YB, Xiong SL, Liu X, Liao DF, Yi GH.
An involvement of SR-B1 mediated PI3K-Akt-eNOS signaling in HDL-induced cyclooxygenase 2expression and prostacyclin production in endothelial cells.
BIOCHEM BIOPH RES CO . 2012 Mar 30;420(1):17-23. (IF 2.985)

6. Hong Q, Qi K, Feng Z, Huang Z, Cui S, Wang L, Fu B, Ding R, Yang J, Chen X, Wu D.
Hyperuricemia induces endothelial dysfunction via mitochondrial Na+/Ca2+ exchanger-mediated mitochondrial calcium overload.
Cell Calcium . 2012 May;51(5):402-10. (IF 4.874)

7. Zhang Y, Liu H, Yin H, Wang W, Zhao X, Du Y.
Nitric oxide mediates alginate oligosaccharides-induced root development in wheat (Triticum aestivum L.).
Plant Physiology and Biochemistry . 2013 Otc;71:49-56. (IF 3.404)

8. Chen W, Wang J, Chen J, Chen J, Chen Z.
Relationship between changes in the cochlear blood flow and disorder of hearing function induced by blast injuryin guinea pigs.
INT J CLIN EXP PATHO . 2013;6(3):375-84. (IF 0.252)

9. Ma S, Zhang Z, Yi F, Wang Y, Zhang X, Li X, Yuan Y, Cao F.
Protective effects of low-frequency magnetic fields on cardiomyocytes from ischemia reperfusion injury via ROS and NO/ONOO-.
Oxid Med Cell Longev . 2013;2013:529173. (IF 5.076)

10. Guo Y, Guo M, Zhao W, Chen K, Zhang P.
Burdock fructooligosaccharide induces stomatal closure in Pisum sativum.
Carbohydrate Polymers . 2013 Sep 12;97(2):731–735. (IF 6.044)

11. Pei H, Yu Q, Xue Q, Guo Y, Sun L, Hong Z, Han H, Gao E, Qu Y, Tao L.
Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress.
Basic Res Cardiol . 2013 Sep;108(5):373. (IF 11.981)

12. Yan T, Cui K, Huang X, Ding S, Zheng Y, Luo Q, Liu X, Zou L.
Assessment of therapeutic efficacy of miR-126 with contrast-enhanced ultrasound in preeclampsia rats.
Placenta . 2014 Jan;35(1):23-9. (IF 3.177)

13. Lu CL, Wang Y, Yuan L, Li Y, Li XY.
The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects the function of pancreatic βcells by improving the function of islet microvascular endothelial cells.
Int J Mol Med . 2014 Nov;34(5):1293-300. (IF 3.098)

14. Ding H, Hong C, Wang Y, Liu J, Zhang N, Shen C, Wei W, Zheng F.
Calreticulin promotes angiogenesis via activating nitric oxide signalling pathway in rheumatoid arthritis.
Clin Exp Immunol . 2014 Nov;178(2):236-44. (IF 3.532)

15. Tang Y, Yin Y, Miao L, Wei B, Zhai K, Ji G.
Nitric oxide enhances extracellular ATP induced Ca2⁺ oscillation in HeLa cells.
Arch Biochem Biophys . 2015 Jan 1;565:68-75. (IF 3.391)

16. Cao J, Xie H, Sun Y, Zhu J, Ying M, Qiao S, Shao Q, Wu H, Wang C.
Sevoflurane post-conditioning reduces rat myocardial ischemia reperfusion injury through an increase in NOS and a decrease in phopshorylated NHE1 levels.
Int J Mol Med . 2015 Dec;36(6):1529-37. (IF 3.098)

17. Wu Q, Zhong ZM, Zhu SY, Liao CR, Pan Y, Zeng JH, Zheng S, Ding RT, Lin QS, Ye Q, Ye WB, Li W, Chen JT.
Advanced oxidation protein products induce chondrocyte apoptosis via receptor for advanced glycationend products-mediated, redox-dependent intrinsic apoptosis pathway.
Apoptosis . 2016 Jan;21(1):36-50. (IF 4.543)

18. An XZ, Zhao ZG, Luo YX, Zhang R, Tang XQ, Hao D, Zhao X, Lv X, Liu D.
Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer.
ONCOTARGET . 2016 Apr 26;7(17):24719-33. (IF 5.168)

19. Yin S, Zhang S, Tong G, Deng L, Liang T, Zhang J.
In vitro vasorelaxation mechanisms of Isoapiole extracted from Lemonfragrant Angelica Root on ratthoracic aorta.
J Ethnopharmacol . 2016 Jul 21;188:229-33. (IF 3.69)

20. Wu KW, Kou ZW, Mo JL, Deng XX, Sun FY.
Neurovascular coupling protects neurons against hypoxic injury via inhibition of potassium currents bygeneration of nitric oxide in direct neuron and endothelium cocultures.
Neuroscience . 2016 Oct 15;334:275-282. (IF 3.056)

21. Li XH, Xue WL, Wang MJ, Zhou Y, Zhang CC, Sun C, Zhu L, Liang K, Chen Y, Tao BB, Tan B, Yu B, Zhu YC.
H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3pexpression.
SCI REP-UK . 2017 Mar 21;7:44807. (IF 3.998)

22. Chen XH, Liu SR, Peng B, Li D, Cheng ZX, Zhu JX, Zhang S, Peng YM, Li H, Zhang TT, Peng XX.
Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens.
Front Immunol . 2017 Mar 6;8:207. (IF 5.085)

23. Huang D, Cui L, Guo P, Xue X, Wu Q, Hussain HI, Wang X, Yuan Z.
Nitric oxide mediates apoptosis and mitochondrial dysfunction and plays a role in growthhormone deficiency by nivalenol in GH3 cells.
SCI REP-UK . 2017 Dec 6;7(1):17079. (IF 3.998)

24. Yu L, Yin M, Yang X, Lu M, Tang F, Wang H.
Calpain inhibitor I attenuates atherosclerosis and inflammation in atherosclerotic rats through eNOS/NO/NF-κB pathway.
CAN J PHYSIOL PHARM . 2018 Jan;96(1):60-67. (IF 1.946)

25. Bao XC, Mao AR, Fang YQ, Fan YH, Wang FF, Ma J, You P.
Simvastatin decreases hyperbaric oxygen-induced acute lung injury by upregulating eNOS.
AM J PHYSIOL-LUNG C . 2018 Feb 1;314(2):L287-L297. (IF 4.406)

26. Zhang J,Yin J,Wang Y,Li B,Zeng X
Apelin impairs myogenic response to induce diabetic nephropathy in mice.
FASEB J . 2018 Aug;32(8):4315-4327. (IF 4.966)

27. Wang YX,Liu HB,Li PS,Yuan WX,Liu B,Liu ST,Qin KR
ROS and NO Dynamics in Endothelial Cells Exposed to Exercise-Induced Wall Shear Stress.
Cell Mol Bioeng. 2018 Oct 8;12(1):107-120. (IF 1.72)

28. Yu W,Chen H,Yang H,Ding J,Xia P,Mei X,Wang L,Chen S,Zou C,Wang LX
Dissecting Molecular Mechanisms Underlying Pulmonary Vascular Smooth Muscle Cell Dedifferentiation in Pulmonary Hypertension: Role of Mutated Caveolin-1 (Cav1F92A)-Bone Marrow Mesenchymal Stem Cells.
Heart Lung Circ. 2019 Oct;28(10):1587-1597. (IF 2.194)

29. Yu WC,Chen HY,Yang HL,Xia P,Zou CW,Sun TW,Wang LX
rBMSC/Cav-1F92A Mediates Oxidative Stress in PAH Rat by Regulating SelW/14-3-3η and CA1/Kininogen Signal Transduction.
Stem Cells Int. 2019 Oct 28;2019:6768571. (IF 3.869)

30. Erfei Zhang,Xiaoying Zhao,Huihui Ma,Dailei Luo,Yanjing Hu,Lichao Hou,Zhikai Luo
A subanesthetic dose of sevoflurane combined with oxygen exerts bactericidal effects and prevents lung injury through the nitric oxide pathway during sepsis
Biomed Pharmacother. 2020 Jul;127:110169.;doi: 10.1016/j.biopha.2020.110169.

31. Wei Liu,Yong Wang,Zheming Leng,Qi Wang,Xiaoxia Duan,Yutong Luo,Yiren Jiang,Li Qin
Nitric oxide plays a crucial role in midgut immunity under microsporidian infection in Antheraea pernyi
Mol Immunol. 2020 Oct;126:65-72.;doi: 10.1016/j.molimm.2020.07.018.

32. Lei Liu,Hexi Zhang,Yijun Shi,Lijian Pan
Prostaglandin E1 Improves Cerebral Microcirculation Through Activation of Endothelial NOS and GRPCH1
J Mol Neurosci. 2020 Dec;70(12):2041-2048.;doi: 10.1007/s12031-020-01610-y.

33. Qin Huang,Meng Gong,Tuantuan Tan,Yunong Lin,Yan Bao,Cuifang Fan
Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP
Nanoscale Res Lett. 2021 Feb 10;16(1):27.;doi: 10.1186/s11671-021-03475-5.

34. Hao Liang,Rongchuan Yue,Chao Zhou,Mengyu Liu,Xi Yu,Shengzhong Lu,Jing Zeng,Zhengping Yu,Zhou Zhou,Houxiang Hu
Cadmium exposure induces endothelial dysfunction via disturbing lipid metabolism in human microvascular endothelial cells
J Appl Toxicol. 2021 May;41(5):775-788.;doi: 10.1002/jat.4115.