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Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。Enzyme Research通过不断追求产品的zui高品质,赢得了世界各地凝血研究实验室的信任。
Enzyme Research Laboratories为生物技术公司,制药行业、医院和大学的研究实验室提供用于的纯化抗凝因子。除了其制造能力,Enzyme Research Laboratories也创新研发领域中的血液凝固技术。
Apolipoprotein-H(β2GP-1)
HAPO-H Apolipoprotein-H(β2GP-1)
Apolipoprotein-H, also known as β2Glycoprotein-1 (β2GP-1) is a plasma glycoprotein that circulates at a concentration of 200 µg/mL (4mM). β2GP-1 has been identified as a constituent of chylomicrons, very low density lipoproteins and high density lipoproteins in Human plasma. It has also been demonstrated to bind phospholipids, heparin and plaets where it can modulate the activity of adenylate (19%). Although the precise function(s) are as yet unknown, β2GP-1 has been shown to interfere with blood coagulation by competitively binding to phospholipids exposed during cell activation or damage. Recent evidence also implicates β2GP-1 as a cofactor recognized by some anti-phospholipid antibodies present in autoimmune disorders such as systemic lupus erythematosus(SLE).
Buffer composition = 20 mM Tris-HCl/0.3 M NaCl /pH 7.3
Extinction Coefficient (1%) = 9.4
Molecular Weight = 48,000 daltons