list biological laboratories公司是世界的科研毒素试剂供应商,其毒素包括霍乱病毒,蛇毒,百日咳毒素等各类毒素,我公司常年低价供应,货期快.有意者请. 百日咳毒素长期现货供应,货号181及180。
listlabs 736A说明书
肉毒杆菌毒素
肉毒杆菌神经毒素(BoNT)是人类已知的毒性大的物质之一。已经鉴定了七种免疫学上不同的神经毒素血清型,命名为A至G型(BoNT / A,BoNT / B,BoNT / C,BoNT / D,BoNT / E,BoNT / F,BoNT / G)。这些肉毒杆菌神经毒素天然产生与一种或多种无毒神经毒素相关蛋白(NAP)复合。NAP对于摄入毒性很重要,因为它们保护神经毒素免受蛋白酶,酸性,热的影响,并且它们也可能在粘膜层的易位中发挥作用。
合成为单个150kDa多肽链,随后通过切割激活复合物的实际神经毒素部分以产生两条链,重链和轻链,其通过单个二硫键连接。对于每种毒素,50kDa轻链是锌依赖性蛋白酶,其切割神经传递期间突触小泡膜融合所必需的单个靶蛋白。A,C和E型神经毒素特异性结合并选择性地切割突触体相关蛋白SNAP-25,而B,D,F和G型切割突触小泡蛋白-2,也称为VAMP-2。靶蛋白的切割抑制神经元之间的神经递质释放,这导致肌肉麻痹。
肉毒杆菌神经毒素毒性
每种毒素很容易分为三个区域,反映出对毒性很重要的三个功能; 特异性底物的结合,易位和切割。重链负责识别突触前膜上的特定神经节苷脂和特定蛋白质受体。重链的易位结构域部分介导轻链穿过内体膜,后靶蛋白被酶促结构域切割。
肉毒杆菌神经毒素在研究中的应用
肉毒杆菌神经毒素是研究中有价值的研究工具,旨在阐明囊泡运输和毒性所涉及的机制,以及了解突触传递的潜在事件。除了使用150kD全毒素的研究之外,重组无毒重链可用于评估毒素的结合特性,并且重组无毒轻链可用于筛选抑制蛋白酶结构域的酶活性。
Botulinum Toxins
肉毒杆菌毒素
抗Botulinum神经毒素,B型(鸡lgY)
产品#和尺寸
#736A(0.1毫克) – 320.00美元
货号 |
品名 |
规格 |
价格 |
list104 |
Cholera Toxin B Subunit (Choleragenoid) in low salt1 |
0.5mg |
4930 |
list106 |
Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC) |
0.2mg |
9775 |
list112 |
Cholera Toxin B Subunit Biotin |
0.2mg |
9775 |
list122 |
Enterotoxin Type B from Staphylococcus aureus1,3 |
0.5mg |
7225 |
list123 |
Enterotoxin Type B Toxoid from Staphylococcus aureus 1,3 |
0.25mg |
8075 |
list139 |
Botulinum Neurotoxin Type B Toxoid |
10µg |
6800 |
list150 |
Diphtheria Toxin, unnicked from Corynebacterium diphtheriae |
1mg |
11050 |
list151 |
Diphtheria Toxoid, from Corynebacterium diphtheriae |
0.5mg |
10625 |
list153 |
Toxin A Toxoid from Clostridium difficile |
100µg |
11900 |
list156 |
Pasteurella Multocida Toxin |
50µg |
8075 |
list160 |
Exotoxin A from Pseudomonas aeruginosa |
1mg |
4420 |
list161 |
Shiga Toxin 1 from Escherichia coli1,4,8 |
10µg |
11900 |
list162 |
Shiga Toxin 2 from Escherichia coli1,4,8 |
10µg |
11050 |
list174 |
Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis |
0.5mg |
9350 |
list175 |
Anthrax PA 63 – Fluorescein Isothiocyanate Conjugate (PAFITC) |
50µg |
7225 |
list180 |
Pertussis Toxin Islet-Activating Protein Lyophilized in buffer |
50µg |
5525 |
list181 |
Pertussis Toxin Islet Activating Protein Lyophilized (Salt-Free) |
50µg |
5525 |
list184 |
Pertussis Toxin Mutant |
50µg |
5525 |
list186 |
FIMBRIAE 2/3 from B. pertussis |
50µg |
5950 |
list187 |
Pertactin from Bordetella pertussus (69 kDa Protein) |
50µg |
4590 |
list193 |
Tetanus Toxin C Fragment |
10µg |
9350 |
list201 |
LPS from Escherichia coli O111:B4 |
5mg |
3230 |
list206 |
LPS, Escherichia coli 0157:H7 |
10.0mg |
4760 |
list225 |
LPS from Salmonella typhimurium |
5mg |
2890 |
list301 |
LPS from Escherichia coli J5 (Rc) |
5mg |
2890 |
list302 |
LPS from Escherichia coli K12, D31m4 (Re) |
5mg |
2890 |
list304 |
LPS from Salmonella minnesota R595 (Re) |
5mg |
2890 |
list314 |
LPS from Escherichia coli K12 strain LCD25 |
1mg |
2890 |
list400 |
HPT™ LPS, highly purified from Bordetella Pertussis 165 |
1mg |
5100 |
list401 |
Lipid A monophosphoryl from Salmonella minnesota R595 |
1mg |
3400 |
list421 |
Ultra Pure LPS from Escherichia coli O111:B4 |
1mg |
3570 |
list423 |
Ultra Pure LPS from Escherichia coli O55:B5 |
1mg |
3570 |
list433 |
LISTÔ HPTÔ, LPS, highly purified Escherichia coli O113 LPS |
1mg |
4080 |
list434 |
Ultra Pure LPS from Salmonella minnesota R595 (Re) |
1mg |
3400 |
list520 |
SNAPtide® Peptide Substrate (o-Abz/Dnp) (U.S. Patent #6,504,006) |
200nmoles |
9775 |
list521 |
SNAPtide® Peptide Substrate (FITC/DABCYL) (U.S. Patent #6,504,006) |
200nmoles |
8500 |
list523 |
SNAPtideÒ Peptide Substrate flP6 (DABCYL/5-IAF), U.S. Patent Pending #61/252,675 |
200nmoles |
8500 |
list525 |
Control Peptide for SNAPtideÒ #520 |
200nmoles |
8500 |
list526 |
Control Peptide for SNAPtide® #521 |
200nmoles |
8500 |
list528 |
Unquenched Calibration Peptide for SNAPtide® 521 |
50nmoles |
2890 |
list529 |
Unquenched Calibration Peptide for SNAPtide® 520 |
50nmoles |
2890 |
list530 |
MAPKKide® Peptide Substrate (o-Abz/Dnp) |
200nmoles |
5100 |
list531 |
MAPKKide® Peptide Substrate (DABCYL/FITC) |
200nmoles |
5100 |
list532 |
MAPKKide® Plus (AMC) Specific Substrate for Anthrax Lethal Factor |
100nmoles |
4250 |
list539 |
Unquenched Calibration Peptide for MAPKKideÒ 530 |
50nmoles |
2890 |
list540 |
VAMPtide® Peptide Substrate (o-Abz/Dnp) |
200nmoles |
8500 |
list541 |
VAMPtide® Peptide Substrate (FITC/DABCYL) |
200nmoles |
8500 |
list542 |
VAMPtide® Peptide Substrate (PL 150, Pya/Nop) |
200nmoles |
8500 |
list549 |
Calibration Fluorophore for VAMPtideÒ 540 |
100nmoles |
2890 |
list550 |
SNAP Etide® Peptide Substrate (o-Abz/Dnp) |
100nmoles |
6800 |
list560 |
SYNTAXtideÒ Peptide Substrate (o-Abz/Dnp) for C. botulinum Type C |
200nmoles |
8500 |
list703 |
Anti-Cholera Toxin B Subunit (Goat) |
0.1ml |
3060 |
list752 |
Anti-Toxin A from Clostridium difficile (Goat) |
0.5ml |
3230 |
list760 |
Anti-Exotoxin A (Goat) |
0.5ml |
3400 |
list781 |
Anti-Protective Antigen from Bacillus anthracis (Goat) affinity purified, Liquid6,7 |
0.1mg |
7055 |
list100B |
Cholera Toxin (Azide Free)1 |
1mg |
3400 |
list101B |
Cholera Toxin1 |
1mg |
3400 |
list101C |
Cholera Toxin1 |
2mg |
5355 |
list116L |
Alpha Toxin from C. septicum4,6,7 |
50µg |
4930 |
list126A |
Epsilon Toxin from C. perfringens1,4,8 |
0.1mg |
5950 |
list128A |
Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3 |
10µg |
2890 |
list128C |
Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3 |
100µg |
5440 |
list130A |
Botulinum Neurotoxin Type A from Clostridium botulinum1,3 |
10µg |
5440 |
list130B |
Botulinum Neurotoxin Type A from Clostridium botulinum1,3 |
100µg |
13600 |
list133L |
Botulinum Neurotoxin Type A Toxoid, Liquid6,7 |
10µg |
5440 |
list136A |
Botulinum Neurotoxin Type B. from Clostridium botulinum 1,3 |
10µg |
5100 |
list136B |
Botulinum Neurotoxin Type B, from Clostridium botulinum1,3 |
100µg |
17000 |
list138A |
Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3 |
10µg |
2890 |
list138B |
Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3 |
100µg |
7225 |
list140A |
Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3 |
10µg |
2890 |
list140B |
Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3 |
100µg |
8925 |
list141A |
Botulinum Neurotoxin Type E, Nicked, from Clostridium botulinum1,3 |
10µg |
8075 |
list146A |
Botulinum Neurotoxin Type D, Nicked, Recombinant from Clostridium botulinum1,3 |
10µg |
5355 |
list149A |
Diphtheria Toxin CRM Mutant |
0.25 mg |
8500 |
list152C |
Toxin A from Clostridium difficile |
100µg |
9010 |
list154A |
Toxin B Toxoid from Clostridium difficile |
20µg |
2890 |
list15 |
Toxin B from Clostridium difficile |
2µg |
2890 |
list155B |
Toxin B from Clostridium difficile |
20µg |
8500 |
list155C |
Toxin B from Clostridium difficile |
200µg |
15300 |
list155L |
Toxin B from Clostridium difficile, Liquid6,7 |
50µg |
9860 |
list157A |
Binary Toxin from Clostridium difficile, A Subunit |
20µg |
5950 |
list158A |
Binary Toxin from Clostridium difficile, B Subunit |
40µg |
5950 |
list159A |
Glutamate Dehydrogenase (GDH) from Clostridium difficile6,7 |
0.1mg |
4930 |
list169A |
Anthrax Lethal Factor (LF-A) , Recombinant from Bacillus anthracis Native Sequence |
0.1mg |
3060 |
list169B |
Anthrax Lethal Factor (LF-A),Recombinant from Bacillus anthracis Native Sequence |
1mg |
12750 |
list169L |
Anthrax Lethal Factor (LF-A),Recomb.from Bacillus anthracis 5,7 |
0.2 mg |
5950 |
list171E |
Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis |
0.5mg |
8755 |
list172B |
Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis |
1mg |
12750 |
list172C |
Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis |
10mg |
39525 |
list172L |
Lethal Factor, Recomb from Bacillus anthracis, froz liq 5,7 |
1.0 mg |
12750 |
list173B |
Anthrax Edema Factor (EF), Recombinant Mutant S447N from Bacillus anthracis |
0.5mg |
16150 |
list176A |
Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis |
0.1mg |
5100 |
list176B |
Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis |
1mg |
16150 |
list177A |
Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis |
50µg |
5950 |
list177B |
Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis |
0.25mg |
11050 |
list178A |
Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis |
0.1mg |
2890 |
list179A |
Pertussis Toxin Islet Activating Protein (in glycerol)6,7 |
50µg |
4845 |
list188L |
Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid5,7 |
50µg |
5270 |
list190A |
Tetanus Toxin2 |
25µg |
2890 |
list190B |
Tetanus Toxin2 |
100µg |
9350 |
list191A |
Tetanus Toxoid |
25µg |
4675 |
list191B |
Tetanus Toxoid |
100µg |
13600 |
list196A |
C-fragment, FITC Conjugate |
10µg |
6800 |
list203A |
LPS, Escherichia coli O55:B5 |
2.5 mg |
3060 |
list500A |
SNAP-25 Recomb Protein Substrate for C. botulinum Type A and E Neurotoxin |
100µg |
5525 |
list510A |
GST Synaptobrevin-2 Protein Recomb. Protein Substrate for C. botulinum Type B,D and F |
100µg |
5950 |
list610A |
Botulinum Neurotoxin Type A Light Chain, Recombinant1 |
10µg |
4760 |
list611A |
Botulinum Neurotoxin Type A Light Chain, GST Fusion, Recombinant1 |
15µg |
4760 |
list612A |
Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain1 |
50µg |
4760 |
list613A |
Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain, GST Fusion1 |
50µg |
4760 |
list620A |
Botulinum Neurotoxin Type B Light Chain, Recombinant1 |
10µg |
8500 |
list622A |
Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain1 |
50µg |
4760 |
list623A |
Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain, GST Fusion1 |
50µg |
4760 |
list62 |
Botulinum Neurotoxin Type C Light Chain, Recombinant1 |
10µg |
8500 |
list630A |
Botulinum Neurotoxin Type D Light Chain, Recombinant1 |
10µg |
5695 |
list650A |
Tetanus Toxin Light Chain, Recombinant |
10µg |
3825 |
list690B |
Receptor for C. botulinum Type A Neurotoxin GST-SV2c luminal domain |
100nmoles |
6800 |
list730A |
Anti-Botulinum Neurotoxin, Type A (Chicken lgY), Liquid6,7 |
0.1mg |
5610 |
list731L |
Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Liquid6,7 |
0.1mg |
5950 |
list736A |
Anti-Botulinum Type B (Chicken lgY), Liquid6,7 |
0.1mg |
5950 |
list753A |
Anti-Clostridium difficile Toxin A (Chicken lgY), Liquid6,7 |
0.1mg |
5780 |
list754A |
Anti-Clostridium difficile Toxin B (Chicken lgY), Liquid6,7 |
0.1mg |
5780 |
list756A |
Anti-Clostridium difficile Glutamate Dehydrogenase, lgY, Liquid6,7 |
0.1mg |
5780 |
list757A |
Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY), Liquid6,7 |
0.1mg |
5780 |
list758A |
Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7 |
0.1mg |
5780 |
list759A |
Biotinylated Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7 |
0.1mg |
5780 |
list761L |
Anti-Shiga Toxin 1 (Rabbit), lgG, Liquid6,7 |
0.5mg |
3400 |
list765L |
Anti-Shiga Toxin 2 (Rabbit), IgG, Liquid6,7 |
0.5mg |
2890 |
list766L |
Anti-Shiga Toxin, Camelid Antibody, VHH, Liquid6,7 |
0.5mg/ml |
5950 |
list768L |
Biotinylated Anti-Lethal Factor from B. anthracis, IgY, Liquid6,7 |
0.1mg |
5950 |
list769B |
Anti-Lethal Factor from Bacillus anthracis (Chicken lgY), Liquid6,7 |
0.2mg |
8500 |
list771B |
Anti-Protective Antigen from Bacillus anthracis (Goat) |
1mg |
2890 |
list772B |
Anti-Lethal Factor from Bacillus anthracis (Goat) |
1.0 mg |
2890 |
list773L |
Anti-Edema Factor from Bacillus anthracis (Goat), Liquid6,7 |
1mg |
2890 |
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