产品简介

BCA（Bicinchoninic acid）法是目前应用比较广泛的蛋白质浓度测定方法。基于双缩脲反应，即在碱性环境下蛋白质将Cu²⁺还原成Cu⁺，产生一种紫蓝色复合物，在562 nm处有高的吸光值，该反应产物的量与蛋白质浓度成正比。BCA蛋白浓度测定法实现了蛋白质浓度测定的简便、灵敏、快速和稳定性。试剂盒中提供的蛋白标准品为用户制作标准曲线提供了便利。

该BCA蛋白浓度测定试剂盒可用于比色皿法检测，也可用于微孔板法检测。前者虽需较大量（100 μL）的蛋白样品，但由于其在检测中使用蛋白样品与BCA工作液的比率为1:20（v/v），从而降低干扰物质带来的影响。后者操作简单方便，仅需少量（10-25 μL）的蛋白样品。不过，由于其在检测中使用蛋白样品与BCA工作液的比率为1:8（v/v），某种程度上限制干扰物质的承受浓度以及降低最低检测水平。我司提供三种规格的BCA蛋白浓度检测试剂盒，比色皿法分别可做50次，250次，500次。酶标法分别可做500次，2500次，以及5000次。

产品特点

1. 灵敏度高，最小检测蛋白量可达0.2 μg，检测浓度下限达到10 μg/mL。
2. 速度快，比一般的BCA蛋白浓度测定试剂盒显色所用时间短。比传统的Lowry法检测速度约快4倍。
3. 线性范围广，20-2000 μg/mL浓度范围内有较好的线性范围。
4. 不受大部分样品中的化学物质的影响，详情见附表1。

产品信息

储存条件

Part Ⅰ中的BCA试剂A、BCA试剂B室温保存；Part Ⅱ中的蛋白标准品（BSA）长时间不用，可置于-25~-15℃保存，有效期1年。

Ver.CN20231205

Q：产品有沉淀怎么办？

A：请 37ºC 温育并伴随搅拌促使其充分溶解。如发现细菌污染，则应丢弃，避免对实验结果造成影响。

Q：请问BCA 蛋白浓度测定时，待测样品是水溶液，可否用纯水直接溶解 BSA 蛋白标准品，而不用试剂盒里的 BSA 蛋白标准配制液？

A：BSA 溶解还是需要使用试剂盒自带的蛋白标准配制液，后续标准品的稀释可以使用水。

Q：该蛋白标准品 BSA 用什么稀释？

A：标准品稀释液为蛋白样品的溶解液，原则上，蛋白样品在什么溶液中，标准品也宜用什么溶液稀释。但也可用 0.9%的NaCl 或 1×PBS 进行稀释。

Q：试剂盒中的BSA 标准品可以另外购买吗？

A：可以的，我们公司提供有单独的 BSA 标准品（货号 36101）。

Q：每次测定时都需要做标准曲线吗？

A：是的，建议每次测定时都做标准曲线。因为BCA法测定时颜色会随着时间的延长不断加深，并且显色反应的速度和温度有关，所以除非精确控制显色反应的时间和温度，否则如需精确测定宜每次都做标准曲线。

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